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BAG4 Knockout Cell Lines

Gene: BAG4

Official Full Name: BAG cochaperone 4provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08367 BAG4 Knockout cell line (HeLa) Human BAG4 1:3~1:6 Negative Online Inquiry
KO08368 BAG4 Knockout cell line (HCT 116) Human BAG4 1:2~1:4 Negative Online Inquiry
KO08369 BAG4 Knockout cell line (HEK293) Human BAG4 1:3~1:6 Negative Online Inquiry
KO08370 BAG4 Knockout cell line (A549) Human BAG4 1:3~1:4 Negative Online Inquiry

Background

BAG4 Gene Knockout Cell Lines are specifically engineered cellular models that have had the BAG4 gene selectively disrupted, resulting in the loss of its expression. These cell lines are invaluable for studying the role of BAG4 in various biological processes, including cellular proliferation, differentiation, and apoptosis. By removing the functionality of BAG4, researchers can investigate its contribution to pathways implicated in cancer biology, neurodegenerative disorders, and stress response mechanisms.

The key mechanism of action for these knockout cell lines lies in their ability to provide a controlled environment to monitor changes in cellular behavior that stem from the absence of BAG4. Analyzing these alterations enables scientists to elucidate BAG4's role in various cellular pathways, including its interactions with chaperone proteins and participation in the regulation of cell survival. This function is crucial for understanding the broader implications of BAG4 in health and disease.

The scientific importance of BAG4 Gene Knockout Cell Lines is profound, with significant applications in both research and clinical settings. These models can aid in drug discovery, where the responsiveness to novel therapeutic agents may vary dramatically between wild-type and knockout variants, thus facilitating the identification of potential targets for intervention. Furthermore, they serve as a platform for functional genomic studies, allowing a deeper understanding of gene function and regulation.

What sets BAG4 Gene Knockout Cell Lines apart from alternatives is their bespoke design, ensuring high specificity and reproducibility. Unlike traditional cell lines that may contain background expression of BAG4, these knockout models provide a clean slate, reducing experimental noise and yielding more reliable data. Additionally, they come with validation data confirming the efficacy of the knockout strategy, enhancing confidence in experimental outcomes.

For researchers and clinicians focused on advancing disease understanding and developing new therapies, BAG4 Gene Knockout Cell Lines offer an essential tool that bridges fundamental science with practical applications. The ability to manipulate a gene of interest while observing its effects on cellular systems makes this product an indispensable asset. Our company specializes in creating high-quality biological products designed to meet the rigorous demands of modern research, cementing our commitment to supporting scientific endeavors across various disciplines.

Please note that all services are for research use only. Not intended for any clinical use.

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