Gene: BABAM2
Official Full Name: BRISC and BRCA1 A complex member 2provided by HGNC
Gene Summary: This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03563 | BABAM2 Knockout cell line (HeLa) | Human | BABAM2 | 1:3~1:6 | Negative | Online Inquiry |
KO03564 | BABAM2 Knockout cell line (HCT 116) | Human | BABAM2 | 1:2~1:4 | Negative | Online Inquiry |
KO03565 | BABAM2 Knockout cell line (HEK293) | Human | BABAM2 | 1:3~1:6 | Negative | Online Inquiry |
KO03566 | BABAM2 Knockout cell line (A549) | Human | BABAM2 | 1:3~1:4 | Negative | Online Inquiry |
BABAM2 Gene Knockout Cell Lines are specialized cellular models engineered to have a complete disruption of the BABAM2 gene, which encodes a protein implicated in various biological processes, including cell adhesion and signaling pathways. By utilizing CRISPR-Cas9 technology, these cell lines offer researchers a robust tool for studying the functional consequences of BABAM2 deficiency, thereby elucidating its role in cellular dynamics, disease mechanisms, and therapeutic targeting.
The primary function of BABAM2 Gene Knockout Cell Lines is to facilitate the investigation of the gene’s contribution to regulatory pathways and cellular behaviors. In these cells, the absence of the BABAM2 protein allows for the analysis of altered signaling cascades and interactions with other cellular components. This knockout approach provides a definitive means of distinguishing the effects of BABAM2 loss from compensatory pathways that often complicate genetic studies.
In a scientific context, these cell lines are vital for advancing research on cancers, metabolic diseases, and developmental disorders where BABAM2 may play a critical role. They serve as experimental platforms for drug screening, biomarker discovery, and evaluating potential gene therapies. The ability to manipulate a single gene while observing the resultant phenotypic and molecular changes significantly enriches our understanding of complex biological systems.
One of the key advantages of using BABAM2 Gene Knockout Cell Lines is their high specificity and reliability compared to other alternatives, such as siRNA knockdowns or overexpression models, which may not fully capture gene function or may lead to incomplete suppression of gene expression. These knockout models allow for reproducible experiments needed in regulatory submissions and clinical trials, thereby ensuring that findings are both robust and relevant.
For researchers and clinicians, the value of BABAM2 Gene Knockout Cell Lines lies in their ability to provide clear insights into BABAM2's role in health and disease, leading to innovative therapeutic strategies and solutions. With our commitment to quality and precision, supported by a highly experienced team in genomic engineering, our gene knockout cell lines stand as a testament to our expertise in delivering cutting-edge biological products for the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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