Gene: B4GALT5
Official Full Name: beta-1,4-galactosyltransferase 5provided by HGNC
Gene Summary: This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The function of the enzyme encoded by this gene is not clear. This gene was previously designated as B4GALT4 but was renamed to B4GALT5. In the literature it is also referred to as beta4GalT2. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33317 | B4GALT5 Knockout cell line (HeLa) | Human | B4GALT5 | 1:3~1:6 | Negative | Online Inquiry |
KO33318 | B4GALT5 Knockout cell line (HCT 116) | Human | B4GALT5 | 1:2~1:4 | Negative | Online Inquiry |
KO33319 | B4GALT5 Knockout cell line (HEK293) | Human | B4GALT5 | 1:3~1:6 | Negative | Online Inquiry |
KO33320 | B4GALT5 Knockout cell line (A549) | Human | B4GALT5 | 1:3~1:4 | Negative | Online Inquiry |
B4GALT5 Gene Knockout Cell Lines are a sophisticated tool designed for the functional study of the B4GALT5 gene, which encodes for the enzyme UDP-galactose: glycoprotein galactosyltransferase 5. This enzyme plays a pivotal role in the biosynthesis of polysialic acid, a molecule critical for the development and maintenance of the nervous system, as well as for cellular interactions during tissue repair and cancer progression. By utilizing CRISPR-Cas9 technology, our B4GALT5 Gene Knockout Cell Lines provide researchers with an invaluable resource for elucidating the gene's specific contributions to pathophysiological processes and for understanding its role in various biological phenomena.
The primary function of these knockout cell lines is to facilitate the study of gene function through the elimination of B4GALT5 expression. This enables researchers to assess cellular responses and physiological changes in a controlled environment. Specifically, the loss of B4GALT5 can help reveal the impacts on cell signaling pathways, adhesion properties, and overall cellular behavior, which can provide critical insights into developmental biology and medical conditions linked to glycosylation abnormalities.
In a research setting, B4GALT5 Gene Knockout Cell Lines hold significant implications for neurobiology and oncology, where understanding the molecular mechanisms driven by polysialic acid is essential for developing potential therapies. Their application extends to drug screening, biomarker discovery, and the formulation of targeted treatments for diseases characterized by aberrant cell behavior.
Compared to other genetic modification tools, our B4GALT5 Gene Knockout Cell Lines offer unparalleled specificity and reliability, minimizing off-target effects commonly associated with traditional knockout methods. Additionally, these cell lines are rigorously validated for consistent performance, ensuring reproducibility in experimental outcomes. This reliability makes them an essential asset for any laboratory focused on advancing their research into glycosylation and cancer biology.
The establishment of B4GALT5 Gene Knockout Cell Lines demonstrates our commitment to empowering researchers and clinicians with cutting-edge biological tools. With a strong foundation in genetic engineering and a focus on quality and precision, our company is dedicated to supporting the scientific community in innovative ways. Choosing our product means investing in a reliable solution that enriches your research capabilities and enhances your understanding of key biological processes.
Please note that all services are for research use only. Not intended for any clinical use.
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