Gene: B3GNT2
Official Full Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2provided by HGNC
Gene Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00172 | B3GNT2 gRNA1-gRNA2 KO plasmid | B3GNT2 | $850 | |||
KO00586 | B3GNT2 Knockout cell line(A-375) | Human | B3GNT2 | 1:3~1:4 | Negative | Online Inquiry |
KO00977 | B3GNT2 Knockout cell line (HCT 116) | Human | B3GNT2 | Negative | Online Inquiry | |
KO04202 | B3GNT2 Knockout cell line (HeLa) | Human | B3GNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO04203 | B3GNT2 Knockout cell line (HEK293) | Human | B3GNT2 | 1:3~1:6 | Negative | Online Inquiry |
KO04204 | B3GNT2 Knockout cell line (A549) | Human | B3GNT2 | 1:3~1:4 | Negative | Online Inquiry |
B3GNT2 Gene Knockout Cell Lines are genetically modified cell lines that have had the B3GNT2 gene inactivated, facilitating the study of its functional role in various biological processes. B3GNT2 encodes a glycosyltransferase involved in the synthesis of specific glycan structures on cell surfaces, thereby influencing cell signaling, adhesion, and interaction with the immune system. By knocking out this gene, researchers can effectively disentangle its contributions to glycan biogenesis and downstream physiological effects.
These cell lines function by utilizing CRISPR/Cas9 technology to create precise deletions in the B3GNT2 gene, resulting in a functional absence of the protein encoded. This allows for a detailed examination of the gene’s role in cellular mechanisms such as tumor progression, immune response modulation, and developmental biology. The ability to analyze these knockout cell lines provides insights that are crucial in both basic research and translational applications, including drug discovery and development of therapeutic interventions.
The scientific importance of B3GNT2 Gene Knockout Cell Lines is underscored by their relevance in research areas such as cancer biology, immunology, and regenerative medicine. Their applications range from understanding disease mechanisms to the development of targeted treatments that utilize glycan structures for therapeutic benefit.
Compared to traditional gene manipulation methods, our B3GNT2 Gene Knockout Cell Lines offer significant advantages. They provide researchers with reliable, consistent models for studying gene functions with reduced off-target effects. Additionally, the ease of use associated with these lines supports high-throughput screening applications, making them invaluable for researchers looking to innovate quickly and efficiently.
These cell lines are particularly valuable to researchers and clinicians seeking to elucidate the complex roles of glycosylation in health and disease. With our commitment to advancing scientific discovery, our company leverages state-of-the-art gene editing technologies and extensive expertise in cell biology to deliver high-quality products like the B3GNT2 Gene Knockout Cell Lines, supporting the next generation of biomedical research and therapeutic solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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