Gene: ART1
Official Full Name: ADP-ribosyltransferase 1provided by HGNC
Gene Summary: ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01168 | Art1 Knockout cell line(B16-F10) | Mouse | Art1 | 1:3~1:4 | Negative | Online Inquiry |
ART1 Gene Knockout Cell Lines are carefully engineered cellular models that exhibit a precise deletion of the ART1 gene, which encodes ADP-ribosyltransferase 1, an enzyme critically involved in modulating cellular responses to stress and inflammation. These knockout cell lines serve as invaluable tools for exploring the biological functions of ART1, providing insights into its role in various cellular pathways, including immune responses, neurodegeneration, and cancer proliferation.
The primary function of the ART1 Gene Knockout Cell Lines lies in their ability to facilitate targeted research in elucidating the mechanisms by which ART1 influences cellular signaling pathways. By removing the ART1 gene, researchers can observe the resultant physiological and biochemical changes, thus discerning the enzyme's contribution to pathologies associated with excessive inflammation and autoimmune disorders. This functional study aids in the identification of potential therapeutic targets and enhances our understanding of disease mechanisms.
Scientifically, these cell lines offer significant applications in both research and clinical settings. They enable the investigation of gene function and regulation, the study of gene-environment interactions, and the development of novel therapeutic strategies. Additionally, these models are particularly relevant in studying pharmacological responses, allowing researchers to ascertain how ART1 absence affects drug metabolism and efficacy.
The distinct advantages of ART1 Gene Knockout Cell Lines include their specificity and reproducibility. Unlike alternative models that may present variable genetic backgrounds or altered gene expression levels, these cell lines provide consistent results across experiments, ensuring reliability and reproducibility in research findings. Furthermore, they are generated under stringent quality control measures to guarantee the integrity of the knockout and the absence of off-target effects.
For researchers and clinicians, the value of the ART1 Gene Knockout Cell Lines lies in their ability to accelerate discovery and enhance the development of therapies targeting ART1-related conditions. By providing a straightforward approach to studying the effects of gene loss in a controlled environment, they facilitate the rapid generation of insightful data that can lead to meaningful advancements in medical science.
Our company specializes in the development of high-quality biological products, offering a wide range of knockout cell lines that are meticulously validated to meet the stringent demands of the research community. With a commitment to innovation and excellence, we empower scientists in their quest for knowledge and therapeutic breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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