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Adipor1 Knockout Cell Lines

Gene: ADIPOR1

Official Full Name: adiponectin receptor 1provided by HGNC

Gene Summary: This gene encodes a protein which acts as a receptor for adiponectin, a hormone secreted by adipocytes which regulates fatty acid catabolism and glucose levels. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. A pseudogene of this gene is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP02303 Adipor1 gRNA1-gRNA2 KO plasmid Adipor1 $850
KO01291 Adipor1 Knockout cell line(CHO-K1) chinese Hamster Adipor1 1:3~1:4 Negative Online Inquiry

Background

Adipor1 Gene Knockout Cell Lines are genetically engineered cell model systems that have had the Adipor1 gene disrupted, allowing for the study of the role of this gene in metabolic processes and obesity-related pathologies. Adipor1 encodes for the adiponectin receptor 1, which plays a critical role in the regulation of glucose levels, fatty acid oxidation, and inflammation through its interaction with adiponectin, a hormone secreted by adipose tissue. By effectively knockout this receptor, these cell lines serve as a valuable tool to elucidate the downstream signaling pathways and biological consequences of altered adiponectin signaling.

The key functional mechanism of Adipor1 gene knockout cell lines centers on their ability to model the metabolic dysfunction often seen in obesity and type 2 diabetes. These cell lines allow researchers to investigate the cellular and molecular mechanisms attributable to the lack of adiponectin receptor signaling, particularly regarding insulin sensitivity and lipid metabolism. Furthermore, they enable the testing of pharmacological agents that can potentially activate or mimic adiponectin actions, offering insights into new therapeutic approaches for metabolic disorders.

From a scientific standpoint, the Adipor1 gene knockout cell lines are critical in bridging the gap between basic research and clinical applications. They provide a powerful platform for studying the intricate relationships between obesity, inflammation, and metabolic syndromes, paving the way for the development of targeted therapies. Compared to traditional animal models or wild-type cell lines, these knockout systems offer greater specificity, reproducibility, and efficiency in experiments focused on adiponectin-mediated pathways.

These cell lines are particularly advantageous for researchers and clinicians due to their ability to produce consistent and reliable data, minimizing variability associated with biological specimens. Their specialized nature allows for the exploration of unique hypotheses regarding metabolic health and disease, accelerating research timelines and fostering innovation.

Our company specializes in the development of advanced biological products, leveraging cutting-edge genetic engineering techniques and a deep understanding of metabolic pathways. We are committed to delivering high-quality tools that empower the scientific community to unlock new knowledge and therapeutic strategies in the realm of metabolic health. By integrating our expertise into the creation of such products, we ensure that researchers and clinicians have access to reliable models that enhance their understanding and application of molecular biology in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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