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AURKC Knockout Cell Lines

Gene: AURKC

Official Full Name: aurora kinase Cprovided by HGNC

Gene Summary: This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35198 AURKC Knockout cell line (HCT 116) Human AURKC 1:2~1:4 Negative Online Inquiry
KO35199 AURKC Knockout cell line (HEK293) Human AURKC 1:3~1:6 Negative Online Inquiry
KO35200 AURKC Knockout cell line (A549) Human AURKC 1:3~1:4 Negative Online Inquiry

Background

AURKC Gene Knockout Cell Lines are specialized, genetically engineered cell lines designed to facilitate the study of AURKC (Aurora Kinase C), a crucial serine/threonine kinase involved in various cellular processes, including mitosis and cell cycle regulation. By creating knockout lines where the AURKC gene has been selectively disrupted, researchers can effectively investigate the functional roles of this kinase and its implications in cellular pathophysiology.

The primary function of AURKC centers on its pivotal role in chromosome segregation during cell division. Through the formation of a functional AURKC protein, proper microtubule attachment and stability are maintained, preventing errors that can lead to aneuploidy. Knockout cell lines provide a powerful platform for elucidating the molecular pathways associated with AURKC, allowing for in-depth studies into its involvement in cancer progression and other diseases linked to cell cycle dysregulation.

The scientific importance of AURKC Gene Knockout Cell Lines lies in their wide applicability in both basic and translational research. They serve as vital tools for drug discovery, target validation, and the examination of genetic interactions. Understanding the precise roles of AURKC can lead to innovative therapeutic strategies, especially in oncology, where aberrations in cell cycle regulation are frequently encountered.

Compared to traditional cell lines that exhibit non-targeted gene expression, AURKC knockout cell lines offer a more accurate and reliable model for studying AURKC's specific biological functions. This targeted approach not only enhances the reproducibility of experiments but also reduces variability, leading to more robust and interpretable data.

For researchers and clinicians seeking to advance their understanding of cell cycle regulation and its implications in health and disease, AURKC Gene Knockout Cell Lines are an invaluable resource. Their high specificity and reliable phenotype provide a solid foundation for uncovering novel insights into potential therapeutic targets.

Our company, a leader in the field of genetic engineering and biological research products, proudly offers AURKC Gene Knockout Cell Lines, underscoring our commitment to supporting the scientific community with innovative, high-quality tools essential for groundbreaking research and advancements in medical science.

Please note that all services are for research use only. Not intended for any clinical use.

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