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ATXN2L Knockout Cell Lines

Gene: ATXN2L

Official Full Name: ataxin 2 likeprovided by HGNC

Gene Summary: This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04733 ATXN2L Knockout cell line (HeLa) Human ATXN2L 1:3~1:6 Negative Online Inquiry
KO04734 ATXN2L Knockout cell line (HCT 116) Human ATXN2L 1:2~1:4 Negative Online Inquiry
KO04735 ATXN2L Knockout cell line (HEK293) Human ATXN2L 1:3~1:6 Negative Online Inquiry
KO04736 ATXN2L Knockout cell line (A549) Human ATXN2L 1:3~1:4 Negative Online Inquiry

Background

ATXN2L Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the ATXN2L gene, which is implicated in various neurodegenerative disorders and cellular homeostasis. These cell lines have undergone a precise genome editing process, typically employing CRISPR-Cas9 technology, to create loss-of-function mutations in the ATXN2L gene. Such knockout models enable researchers to dissect the molecular pathways influenced by ATXN2L, providing valuable insight into its role in cellular physiology and disease mechanisms.

The primary function of these cell lines revolves around elucidating the biological consequences of ATXN2L deficiency. By observing changes in cellular behavior, gene expression profiles, and downstream effects on signaling pathways, researchers can gain a deeper understanding of how dysregulation of this gene contributes to pathological states. These knockouts are vital for investigating therapeutic targets and validating the efficacy of potential treatments in both research and clinical settings.

In addition to their importance in basic science, ATXN2L Gene Knockout Cell Lines play a critical role in drug discovery and development. They provide a robust platform for screening pharmacological compounds, assessing neuroprotective strategies, and evaluating the effects of genetic modification in various experimental conditions. Compared to traditional models, these knockout cell lines offer enhanced specificity, reduced variability, and increased reproducibility, making them indispensable tools in modern biomedical research.

The unique selling points of our ATXN2L Gene Knockout Cell Lines include their high-quality and validated genome edits, comprehensive background information for optimal use, and ease of handling, ensuring that researchers can quickly adapt these models into their experimental workflows. This versatility and reliability are particularly valuable to scientists aiming to generate meaningful data that can translate into tangible therapeutic breakthroughs.

Our commitment to innovation in genetic engineering and extensive experience in producing cutting-edge biological products solidify our position as a trusted partner for researchers and clinicians dedicated to advancing knowledge in neurobiology and genetic disorders. With ATXN2L Gene Knockout Cell Lines, you can explore new frontiers in the understanding of molecular genetics and disease, paving the way for future advancements in therapeutic interventions.

Please note that all services are for research use only. Not intended for any clinical use.

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