Gene: ATXN10
Official Full Name: ataxin 10provided by HGNC
Gene Summary: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28781 | ATXN10 Knockout cell line (HeLa) | Human | ATXN10 | 1:3~1:6 | Negative | Online Inquiry |
KO28782 | ATXN10 Knockout cell line (HCT 116) | Human | ATXN10 | 1:2~1:4 | Negative | Online Inquiry |
KO28783 | ATXN10 Knockout cell line (HEK293) | Human | ATXN10 | 1:3~1:6 | Negative | Online Inquiry |
KO28784 | ATXN10 Knockout cell line (A549) | Human | ATXN10 | 1:3~1:4 | Negative | Online Inquiry |
ATXN10 Gene Knockout Cell Lines are specialized cellular models developed for the functional study of the ATXN10 gene, which is implicated in various neurodegenerative disorders, particularly spinocerebellar ataxia. These cell lines have been meticulously engineered using CRISPR-Cas9 technology to create specific deletions in the ATXN10 gene, thus enabling the investigation of its biological role, associated pathways, and the molecular mechanisms contributing to pathology.
The primary function of these knockout cell lines lies in their ability to facilitate targeted studies on gene expression, protein function, and the interaction of ATXN10 with other cellular components. By eliminating the expression of ATXN10, researchers can elucidate its impact on cellular processes such as neuronal survival, stress response, and RNA metabolism, thereby contributing to a better understanding of neurodegenerative mechanisms.
The scientific importance of ATXN10 Gene Knockout Cell Lines extends across both basic and applied research. In the context of neurobiology, these cell lines serve as an invaluable tool for exploring the etiology of spinocerebellar ataxias, offering insights that could pave the way for novel therapeutic strategies. In clinical settings, findings derived from these models may inform the development of gene-targeted treatments and assist in the identification of biomarkers for disease progression.
One of the distinctive advantages of our ATXN10 Gene Knockout Cell Lines is their high specificity and reproducibility, allowing for consistent experimental outcomes. Unlike traditional cell lines, these engineered models provide a more accurate representation of cellular responses associated with ATXN10 deficiency. Furthermore, they are compatible with various downstream applications, including drug screening, gene editing verification, and mechanistic studies.
For researchers and clinicians alike, the value of ATXN10 Gene Knockout Cell Lines is unmistakable. They embody an essential resource for those seeking to unlock new horizons in neurodegenerative research and therapeutic development, enhancing the potential for breakthrough discoveries.
Our company prides itself on its extensive expertise in genetic engineering and cell line development, ensuring that our biological products are of the highest quality, scientifically validated, and tailored to meet the needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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