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ATP9B Knockout Cell Lines

Gene: ATP9B

Official Full Name: ATPase phospholipid transporting 9B (putative)provided by HGNC

Gene Summary: Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in endocytosis; phospholipid translocation; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in perinuclear region of cytoplasm and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31254 ATP9B Knockout cell line (HeLa) Human ATP9B 1:3~1:6 Negative Online Inquiry
KO31255 ATP9B Knockout cell line (HCT 116) Human ATP9B 1:2~1:4 Negative Online Inquiry
KO31256 ATP9B Knockout cell line (HEK293) Human ATP9B 1:3~1:6 Negative Online Inquiry
KO31257 ATP9B Knockout cell line (A549) Human ATP9B 1:3~1:4 Negative Online Inquiry

Background

ATP9B Gene Knockout Cell Lines are sophisticated biological tools designed for the study of the ATP9B gene's role in cellular processes. These cell lines have been engineered using advanced CRISPR/Cas9 technology to create specific deletions in the ATP9B gene, enabling researchers to investigate the gene's functions in a controlled environment. This knockout model provides a unique opportunity to explore the consequences of ATP9B loss on cellular physiology, metabolism, and signaling pathways.

The primary function of ATP9B relates to its role as a phospholipid flippase, which is crucial for maintaining membrane dynamics and cellular lipid homeostasis. By knocking out ATP9B, researchers can observe altered membrane properties and assess how these changes affect cell behavior, differentiation, and response to external stimuli. The mechanistic insights gained from such studies can shed light on ATP9B's involvement in various physiological and pathological conditions, including neurodegenerative diseases, metabolic disorders, and cancer.

In research and clinical settings, these knockout cell lines serve as valuable models for drug discovery and development, allowing for the assessment of therapeutic interventions that target ATP9B-related pathways. The ability to manipulate the ATP9B gene facilitates the identification of potential biomarkers for diseases associated with its dysfunction, paving the way for innovative diagnostic and treatment strategies.

Compared to traditional methods, such as RNA interference or chemical inhibitors, ATP9B Gene Knockout Cell Lines offer a more permanent and specific means to study gene function. This level of precision minimizes off-target effects and provides clearer insights into the direct consequences of gene knockout.

For researchers and clinicians, the value of ATP9B Gene Knockout Cell Lines lies in their potential to advance our understanding of gene function in health and disease. They enable experimentation that drives innovation and fosters breakthrough discoveries. As a company dedicated to delivering high-quality biological products, we pride ourselves on our expertise in genetic engineering and our commitment to supporting the scientific community with reliable, cutting-edge research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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