Gene: ATP13A2
Official Full Name: ATPase cation transporting 13A2provided by HGNC
Gene Summary: This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00334 | ATP13A2 Knockout cell line (HeLa) | Human | ATP13A2 | 1:3~1:6 | Negative | Online Inquiry |
KO20144 | ATP13A2 Knockout cell line (HCT 116) | Human | ATP13A2 | 1:2~1:4 | Negative | Online Inquiry |
KO20145 | ATP13A2 Knockout cell line (HEK293) | Human | ATP13A2 | 1:3~1:6 | Negative | Online Inquiry |
KO20146 | ATP13A2 Knockout cell line (A549) | Human | ATP13A2 | 1:3~1:4 | Negative | Online Inquiry |
ATP13A2 Gene Knockout Cell Lines are advanced biological tools specifically engineered to study the functions and implications of the ATP13A2 gene, which is implicated in neurodegenerative diseases such as Parkinson's disease. These cell lines have been genetically modified to disrupt the ATP13A2 gene, enabling researchers to investigate the downstream effects of gene knockout on cellular physiology, metabolic pathways, and neurodegenerative mechanisms.
The primary function of the ATP13A2 gene is associated with lysosomal function and metal ion transport, playing a crucial role in maintaining cellular homeostasis. By utilizing these knockout cell lines, researchers can elucidate the role of ATP13A2 in cellular processes, improving our understanding of how its dysfunction contributes to disease pathology. The mechanisms studied include alterations in autophagy, oxidative stress response, and cellular signaling pathways that are pivotal in neuronal health.
Scientifically, ATP13A2 knockout cell lines hold significant importance in both research and clinical contexts. They serve as vital platforms to study disease modeling, drug discovery, and therapeutic interventions tailored for neurodegenerative conditions. These cell lines can also facilitate the development of targeted treatments by uncovering novel therapeutic targets associated with ATP13A2-related pathways.
Compared to conventional cell lines, ATP13A2 knockout models offer specific advantages by providing a tailored tool with a direct connection to relevant disease mechanisms. The precision of these models in mimicking the biological consequences of gene knockout enhances the reliability and relevance of experimental results, which is essential for advancing scientific knowledge and therapeutic strategies.
For researchers and clinicians striving to make breakthroughs in neurodegenerative disease studies, ATP13A2 Gene Knockout Cell Lines represent a valuable asset, combining innovative genetic engineering with practical applications. Our company prides itself on being at the forefront of providing top-tier biological products, utilizing cutting-edge technologies to support the research community in their pursuit of scientific advancement and the development of next-generation therapies.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.