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ATP11B Knockout Cell Lines

Gene: ATP11B

Official Full Name: ATPase phospholipid transporting 11B (putative)provided by HGNC

Gene Summary: P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd(2+). Another subfamily transports non-heavy metal ions, such as H(+), Na(+), K(+), or Ca(+). A third subfamily transports amphipaths, such as phosphatidylserine.[supplied by OMIM, Feb 2005]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29707 ATP11B Knockout cell line (HeLa) Human ATP11B 1:3~1:6 Negative Online Inquiry
KO29708 ATP11B Knockout cell line (HCT 116) Human ATP11B 1:2~1:4 Negative Online Inquiry
KO29709 ATP11B Knockout cell line (HEK293) Human ATP11B 1:3~1:6 Negative Online Inquiry
KO29710 ATP11B Knockout cell line (A549) Human ATP11B 1:3~1:4 Negative Online Inquiry

Background

ATP11B Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to lack the ATP11B gene, which encodes a member of the P-type ATPase family involved in anionic phospholipid transport. These knockout cell lines serve as powerful tools for researchers investigating the physiological roles of ATP11B in cellular processes such as lipid homeostasis, membrane dynamics, and cellular signaling pathways. By disrupting the ATP11B gene, researchers can study the downstream effects of its absence, revealing critical insights into its contributions to cellular function and disease.

The key mechanisms underlying the utility of ATP11B Gene Knockout Cell Lines include their ability to facilitate the elucidation of gene function through comparative analyses with wild-type cell lines. This knockout model enables the identification of compensatory mechanisms that might arise in the absence of ATP11B, uncovering new targets for therapeutic intervention in diseases linked to phospholipid transport disturbances. The potential applications of these cell lines span various fields, including cancer research, neurobiology, and studies of metabolic disorders, making them invaluable in both basic and applied research.

In comparison to alternative models, such as RNA interference approaches or CRISPR-Cas9 gene editing, ATP11B Gene Knockout Cell Lines offer stable expression changes that provide reliable experimental outcomes over time. This stability enhances reproducibility and reduces variability in experimental results, making them preferable for long-term studies.

For researchers and clinicians alike, the availability of ATP11B Gene Knockout Cell Lines represents a major advancement in the exploration of cellular biology and disease mechanisms. By utilizing these specialized tools, stakeholders can accelerate scientific discoveries that ultimately contribute to the development of innovative therapeutic strategies.

Our company, with years of expertise in providing high-quality biological research products, is dedicated to supporting the research community by offering meticulously designed gene knockout cell lines that meet stringent scientific standards. We are committed to empowering researchers to unlock new dimensions of cellular biology through innovative solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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