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ATAD2B Knockout Cell Lines

Gene: ATAD2B

Official Full Name: ATPase family AAA domain containing 2Bprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the AAA ATPase family. This family member includes an N-terminal bromodomain. It has been found to be localized to the nucleus, partly to replication sites, consistent with a chromatin-related function. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21757 ATAD2B Knockout cell line (HeLa) Human ATAD2B 1:3~1:6 Negative Online Inquiry
KO21758 ATAD2B Knockout cell line (HCT 116) Human ATAD2B 1:2~1:4 Negative Online Inquiry
KO21759 ATAD2B Knockout cell line (HEK293) Human ATAD2B 1:3~1:6 Negative Online Inquiry
KO21760 ATAD2B Knockout cell line (A549) Human ATAD2B 1:3~1:4 Negative Online Inquiry

Background

ATAD2B Gene Knockout Cell Lines are specially engineered cell lines in which the ATAD2B gene has been disrupted, allowing researchers to study the physiological and pathological roles of this specific gene in various biological contexts. ATAD2B, a member of the AAA+ ATPase family, is involved in chromatin remodeling and gene regulation, making it a critical component in cellular processes such as proliferation, differentiation, and stress responses. The knockout of this gene provides a unique opportunity to explore its function by observing the resulting phenotypic changes, which can further elucidate the mechanisms underlying various diseases, including cancer.

The primary mechanism by which these cell lines function is through the inactivation of ATAD2B, leading to decreased ATPase activity and altered chromatin structure. This results in modifications to gene expression patterns, providing insights into the gene’s role in oncogenesis and other disease states. Researchers can utilize these knockout cell lines to model specific pathways and test potential therapies targeting ATAD2B-driven processes.

The scientific importance of ATAD2B Gene Knockout Cell Lines lies in their application to basic research and translational medicine. They serve as valuable tools in high-throughput screening efforts for drug discovery and provide a model for understanding the contributions of ATAD2B in cellular behavior and disease development. Moreover, the insights gained from utilizing these models can drive innovations in targeted therapies.

One of the unique selling points of our ATAD2B Gene Knockout Cell Lines is their specificity and reliability, with each line carefully validated for successful knockout efficiency. Compared to other gene manipulation methods, our product allows for more precise assessments of gene function without the confounding effects associated with incomplete knockdown or off-target effects.

For researchers and clinicians, the ability to manipulate the ATAD2B gene with high fidelity offers substantial value in both understanding fundamental biological processes and developing novel therapeutic strategies. The insights derived from our cell lines can accelerate the pace of discovery in numerous fields, including cancer research and therapeutic development.

Our company is dedicated to providing high-quality biological products that empower researchers to make breakthroughs in their work. With a focus on innovation and scientific excellence, our ATAD2B Gene Knockout Cell Lines exemplify our commitment to advancing research and improving human health.

Please note that all services are for research use only. Not intended for any clinical use.

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