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ASXL2 Knockout Cell Lines

Gene: ASXL2

Official Full Name: ASXL transcriptional regulator 2provided by HGNC

Gene Summary: This gene encodes a member of a family of epigenetic regulators that bind various histone-modifying enzymes and are involved in the assembly of transcription factors at specific genomic loci. Naturally occurring mutations in this gene are associated with cancer in several tissue types (breast, bladder, pancreas, ovary, prostate, and blood). This gene plays an important role in neurodevelopment, cardiac function, adipogenesis, and osteoclastogenesis. [provided by RefSeq, Feb 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19623 ASXL2 Knockout cell line (HeLa) Human ASXL2 1:3~1:6 Negative Online Inquiry
KO19624 ASXL2 Knockout cell line (HCT 116) Human ASXL2 1:2~1:4 Negative Online Inquiry
KO19625 ASXL2 Knockout cell line (HEK293) Human ASXL2 1:3~1:6 Negative Online Inquiry
KO19626 ASXL2 Knockout cell line (A549) Human ASXL2 1:3~1:4 Negative Online Inquiry

Background

ASXL2 Gene Knockout Cell Lines are genetically engineered cellular models that have had the ASXL2 (Additional Sex Comb- like 2) gene inactivated, providing a critical tool in the study of various biological and disease processes. ASXL2 is implicated in several pathways, notably in hematopoiesis and chromatin remodeling, making its knockout significant for researchers seeking to understand gene function and regulatory mechanisms. These cell lines enable the exploration of the downstream effects of ASXL2 disruption on cellular behavior, gene expression, and overall phenotype.

The mechanism underlying the utility of ASXL2 knockout cell lines lies in their ability to mimic mutations found in certain cancers and genetic disorders, allowing for in-depth investigation into disease pathogenesis. Researchers can utilize these models to delineate the role of ASXL2 in cellular proliferation, differentiation, and response to therapies. Notably, these knockouts facilitate high-throughput screening and functional assays that contribute to drug discovery and development, potentially leading to novel therapeutic interventions.

In comparison to other genetic knockout systems, ASXL2 Gene Knockout Cell Lines offer unique advantages such as reproducibility and user-friendly protocols. These lines can be integrated into established experimental workflows, yielding significant time savings and reliable data. They represent a valuable resource for both academic and industry researchers focused on cancer biology, hematology, and epigenetics.

For researchers and clinicians, ASXL2 Gene Knockout Cell Lines are imperative in advancing the understanding of gene function within a pathophysiological context, ultimately leading to enhanced patient outcomes through tailored treatments. Our company specializes in providing high-quality, ready-to-use biological products, leveraging cutting-edge genetic engineering technologies to support the scientific community's quest for knowledge and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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