Gene: ASIC2
Official Full Name: acid sensing ion channel subunit 2provided by HGNC
Gene Summary: This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO39134 | ASIC2 Knockout cell line (A549) | Human | ASIC2 | 1:3~1:4 | Negative | Online Inquiry |
ASIC2 Gene Knockout Cell Lines are specifically engineered cellular systems designed to study the functional role of the acid-sensing ion channel 2 (ASIC2) gene. These cell lines have been meticulously created through targeted gene disruption techniques, leading to a complete knockout of the ASIC2 gene, allowing researchers to model and scrutinize the physiological and pathological implications of ASIC2 deficiency.
The primary mechanism of action exhibited by ASIC2 knockout cell lines lies in the absence of ASIC2 channels, which are integral to the sensory pathways for detecting sudden increases in extracellular acidity. By analyzing these cell lines, researchers can investigate a variety of biological processes, including neuronal signaling, synaptic plasticity, and the mechanisms underlying pain perception and respiratory function. This capability is especially vital for studying conditions like ischemic injury, neurodegenerative disorders, and chronic pain syndromes where ASIC2 channels are implicated.
The scientific importance of ASIC2 Gene Knockout Cell Lines extends into both basic and translational research domains. In clinical settings, they can offer insights into potential therapeutic targets for pain management or neuroprotection, providing a platform to test novel pharmacological interventions. Furthermore, their use in research can drive the development of genetic models that reflect ASIC2's role in various disease phenotypes.
One of the standout advantages of our ASIC2 Gene Knockout Cell Lines is the precision with which they have been generated, ensuring reproducibility and reliability in experimental outcomes. Unlike traditional knockout models or generalized cell lines, these specially designed systems allow for more detailed and specific investigations into ASIC2's functions and its interaction with other cellular components.
For researchers and clinicians aiming to understand the nuances of ASIC2’s contribution to health and disease, our cell lines represent a powerful tool in the ongoing quest to uncover the complexities of ion channel biology. By leveraging differentiated cellular responses and insights derived from these lines, users can expect to enhance their research quality and clinical applications.
With a strong foundation in genetic engineering and cell biology, our company stands at the forefront of biological product development, committed to providing cutting-edge tools like ASIC2 Gene Knockout Cell Lines that empower scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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