Gene: ARPC4
Official Full Name: actin related protein 2/3 complex subunit 4provided by HGNC
Gene Summary: This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00249 | ARPC4 gRNA3-gRNA4 KO plasmid | ARPC4 | $850 | |||
GP00250 | ARPC4 gRNA1-gRNA2 KO plasmid | ARPC4 | $850 | |||
KO00643 | ARPC4 Knockout cell line(A549) | Human | ARPC4 | 1:3~1:4 | Negative | Online Inquiry |
ARPC4 Gene Knockout Cell Lines are specialized cellular models developed through targeted genome-editing techniques to abrogate the expression of the actin-regulating protein ARPC4. This gene plays a pivotal role in the actin polymerization process, which is essential for maintaining cellular structure, motility, and various intracellular processes. By eliminating the ARPC4 gene, these knockout cell lines serve as invaluable tools for researchers seeking to investigate the functional consequences of reduced or absent ARPC4 activity.
The mechanism underlying the utility of ARPC4 knockout cell lines lies in their ability to mimic specific pathophysiological conditions where actin dynamics are altered. With the loss of ARPC4, researchers can study the downstream effects on actin filament organization, cell migration, and signal transduction pathways, thereby gaining insights into various diseases, including cancer metastasis and neurodegenerative disorders. Moreover, these cell lines can be employed in drug discovery, therapeutic screening, and the study of cellular responses to environmental stressors.
One of the key advantages of using ARPC4 Gene Knockout Cell Lines over alternative models is their specificity and replicability in simulating precise genetic conditions. Unlike transient transfection models which may have variable expression levels, these knockout lines provide a stable and consistent platform for long-term studies. Moreover, they are suited for high-throughput screening applications, making them an asset for both academic and clinical research environments.
For researchers and clinicians, the value of ARPC4 Gene Knockout Cell Lines extends beyond their experimental utility; they signify a step towards understanding complex biological mechanisms and ultimately contribute to the development of targeted therapies. Their application can lead to breakthrough discoveries in understanding the mechanistic links between actin dynamics and disease states.
At [Your Company Name], we pride ourselves on our deep expertise in gene editing technologies and our commitment to providing high-quality biological products that serve as powerful tools for scientific discovery and clinical advancement. Our ARPC4 Gene Knockout Cell Lines exemplify our dedication to supporting the research community with innovative solutions that drive scientific progress.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.