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ARID5B Knockout Cell Lines

Gene: ARID5B

Official Full Name: AT-rich interaction domain 5Bprovided by HGNC

Gene Summary: This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06525 ARID5B Knockout cell line (HeLa) Human ARID5B 1:3~1:6 Negative Online Inquiry
KO06526 ARID5B Knockout cell line (HCT 116) Human ARID5B 1:2~1:4 Negative Online Inquiry
KO06527 ARID5B Knockout cell line (HEK293) Human ARID5B 1:3~1:6 Negative Online Inquiry
KO06528 ARID5B Knockout cell line (A549) Human ARID5B 1:3~1:4 Negative Online Inquiry

Background

ARID5B Gene Knockout Cell Lines are specialized cell lines engineered to lack the ARID5B gene, which plays a crucial role in regulating gene expression and development of various biological processes, including immune response and cell proliferation. By utilizing CRISPR/Cas9 gene editing technology, these cell lines enable researchers to investigate the specific functions and mechanisms associated with ARID5B in both normal and pathological states. The knockout of this gene provides a powerful tool for studying its involvement in diseases such as lymphomas, autoimmune disorders, and certain types of cancer, where dysregulation of gene expression often leads to poor clinical outcomes.

The key function of these knockout cell lines lies in their ability to produce insights into the biological pathways influenced by ARID5B. Researchers can perform a variety of assays to observe changes in cellular behavior, gene expression profiles, and protein interactions, thereby delineating ARID5B’s contribution to critical cellular processes. In clinical settings, understanding these mechanisms can pave the way for potential therapeutic targets, contributing to the development of innovative strategies for disease intervention.

Compared to other cell line models, ARID5B Gene Knockout Cell Lines provide a unique advantage due to their precision in gene editing, enabling more reliable observations of ARID5B's functional roles. Additionally, these cell lines can be cultivated under standard laboratory conditions, facilitating easy integration into existing experimental workflows.

For researchers and clinicians, the value of ARID5B Gene Knockout Cell Lines lies in their ability to unlock fundamental biological insights and inform treatment modalities through targeted research. The potential applications in drug discovery and therapeutic development are vast—positioning these cell lines at the forefront of molecular and translational biology studies.

Our company is dedicated to advancing scientific research by providing high-quality biological products, and our expertise in gene editing technologies ensures that our ARID5B Gene Knockout Cell Lines are optimized for reliability and performance, enabling researchers to make significant advancements in their fields.

Please note that all services are for research use only. Not intended for any clinical use.

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