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ARHGAP23 Knockout Cell Lines

Gene: ARHGAP23

Official Full Name: Rho GTPase activating protein 23provided by HGNC

Gene Summary: The RHO (see ARHA; MIM 165390) family of small GTPases are involved in signal transduction through transmembrane receptors, and they are inactive in the GDP-bound form and active in the GTP-bound form. GTPase-activating proteins, such as ARHGAP23, inactivate RHO family proteins by stimulating their hydrolysis of GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19714 ARHGAP23 Knockout cell line (HeLa) Human ARHGAP23 1:3~1:6 Negative Online Inquiry
KO19715 ARHGAP23 Knockout cell line (HCT 116) Human ARHGAP23 1:2~1:4 Negative Online Inquiry
KO19716 ARHGAP23 Knockout cell line (HEK293) Human ARHGAP23 1:3~1:6 Negative Online Inquiry
KO19717 ARHGAP23 Knockout cell line (A549) Human ARHGAP23 1:3~1:4 Negative Online Inquiry

Background

ARHGAP23 Gene Knockout Cell Lines are invaluable biological tools engineered to facilitate research on the role of the ARHGAP23 gene, which encodes a member of the Rho GTPase-activating protein family. This product is designed to create a definitive absence of the ARHGAP23 protein, enabling scientists to investigate its function and regulatory pathways in various cellular contexts.

Through targeted CRISPR/Cas9 gene-editing technology, these knockout cell lines effectively disable the ARHGAP23 gene, allowing researchers to study the downstream effects of this gene's absence in cellular signaling and behavior. The loss of ARHGAP23 has implications in processes such as cytoskeletal dynamics, cell migration, and morphology, making these cell lines crucial for understanding fundamental biological processes and disease mechanisms involving cellular communication and motility.

In scientific research, ARHGAP23 is being explored for its potential involvement in cancer biology, neurodegenerative diseases, and other pathologies linked to aberrant cell movement and signal transduction. This specific knockout model can serve as a rugged platform for drug discovery, functional genomics, and validating therapeutic targets, making it a critical resource for both academic and clinical research settings.

Compared to conventional cell lines, ARHGAP23 Gene Knockout Cell Lines provide a precise and reproducible model for studying ARHGAP23-related pathways and their contributions to disease. These cell lines offer higher specificity than inhibitors or siRNAs, mitigating off-target effects, and enhancing the accuracy of experimental outcomes.

For researchers, clinicians, and pharmaceutical developers striving for clarity in the complex web of cellular interactions, ARHGAP23 Gene Knockout Cell Lines present a high-value solution. They not only deepen our understanding of cellular processes but also provide potential avenues for novel therapeutic interventions.

With a strong foundation in genetic engineering and a commitment to advancing biological research, our company stands at the forefront of developing cutting-edge biological products, ensuring that our clients have access to the most reliable and innovative tools in their research arsenal.

Please note that all services are for research use only. Not intended for any clinical use.

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