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ARHGAP22 Knockout Cell Lines

Gene: ARHGAP22

Official Full Name: Rho GTPase activating protein 22provided by HGNC

Gene Summary: This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19718 ARHGAP22 Knockout cell line (HeLa) Human ARHGAP22 1:3~1:6 Negative Online Inquiry
KO19719 ARHGAP22 Knockout cell line (HCT 116) Human ARHGAP22 1:2~1:4 Negative Online Inquiry
KO19720 ARHGAP22 Knockout cell line (HEK293) Human ARHGAP22 1:3~1:6 Negative Online Inquiry
KO19721 ARHGAP22 Knockout cell line (A549) Human ARHGAP22 1:3~1:4 Negative Online Inquiry

Background

ARHGAP22 Gene Knockout Cell Lines are engineered cellular models specifically designed to study the biological functions and pathways associated with the ARHGAP22 gene, which encodes a member of the Rho GTPase-activating protein family. These knockout cell lines serve as a powerful tool for investigating the gene's role in cellular processes such as cytoskeletal dynamics, cell migration, and signaling pathways influencing various diseases.

The primary function of ARHGAP22 is to regulate Rho GTPases, which are critical for actin cytoskeleton organization and consequently affect processes like cell adhesion, motility, and proliferation. By eliminating the expression of the ARHGAP22 gene in these cell lines, researchers can observe the resultant phenotypic changes and identify specific molecular interactions impacted by this gene, providing insights into its contribution to processes underlying diseases such as cancer and neurological disorders.

The scientific importance of ARHGAP22 Gene Knockout Cell Lines lies in their utility in both basic and applied research. In clinical settings, they can be employed to screen compounds modulating ARHGAP22 activity or as models to test therapeutic approaches targeting related signaling pathways. Additionally, their use in high-throughput screening assays facilitates the discovery of novel drugs that could intervene in ARHGAP22-mediated pathologies.

Compared to other cell models, these knockout lines offer distinct advantages. They provide a more precise understanding of ARHGAP22 function without the interference from compensatory mechanisms often present in wild-type cells. Furthermore, the specificity and reproducibility of these lines enhance experimental rigor, making them an attractive choice for advanced research applications.

The value of ARHGAP22 Gene Knockout Cell Lines to researchers and clinicians is significant, as they empower the exploration of groundbreaking insights into gene function and disease mechanisms. By utilizing these models, users can drive innovation in research and development, ultimately leading to enhanced therapeutic options for patients.

With a strong foundation in genetic engineering and a commitment to advancing scientific research, our company brings years of expertise in producing high-quality biological products tailored for the needs of the research community. Our ARHGAP22 Gene Knockout Cell Lines exemplify this dedication, providing researchers with the robust tools necessary to explore the complexities of gene function.

Please note that all services are for research use only. Not intended for any clinical use.

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