Gene: ARFIP1
Official Full Name: ARF interacting protein 1provided by HGNC
Gene Summary: Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27744 | ARFIP1 Knockout cell line (HeLa) | Human | ARFIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO27745 | ARFIP1 Knockout cell line (HCT 116) | Human | ARFIP1 | 1:2~1:4 | Negative | Online Inquiry |
KO27746 | ARFIP1 Knockout cell line (HEK293) | Human | ARFIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO27747 | ARFIP1 Knockout cell line (A549) | Human | ARFIP1 | 1:3~1:4 | Negative | Online Inquiry |
ARFIP1 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the functional role of the ARFIP1 gene, which is implicated in various cellular processes, including endocytosis and intracellular trafficking. These knockout cell lines are created through advanced CRISPR-Cas9 gene editing technology, ensuring the precise deletion of the ARFIP1 gene, which subsequently allows researchers to study its impact on cellular behavior and signal transduction pathways.
The key mechanism of these knockout cell lines lies in their ability to facilitate the examination of gene function in the absence of ARFIP1. This opens up avenues for understanding the molecular underpinnings of diseases where ARFIP1 is involved, such as certain cancers and neurological disorders. By comparing knockout cells to their wild-type counterparts, researchers can elucidate the gene's role in regulating various cellular processes and contribute to the identification of potential therapeutic targets.
From a scientific perspective, ARFIP1 Gene Knockout Cell Lines hold significant value in both research and clinical settings. They enhance our understanding of gene function and expression, critical in developing novel therapeutic strategies and drug testing. Moreover, these cell lines can be leveraged in high-throughput screening assays to identify compounds that may restore normal function in ARFIP1-related pathologies.
Compared to alternative models, these knockout cell lines offer unparalleled specificity and reproducibility. While traditional methods involve the use of inhibitors or RNA interference that may lead to off-target effects, the precise gene knockout achieved with CRISPR-Cas9 ensures a more accurate representation of ARFIP1's functional loss. This increases reliability in experimental outcomes, making findings more robust and facilitating clearer interpretations.
For researchers and clinicians focused on gene function, cancer biology, or drug development, ARFIP1 Gene Knockout Cell Lines provide an invaluable resource for dissecting complex biological pathways and accelerating discoveries in translational medicine. With a commitment to high-quality biological products, our company steadfastly supports scientific research through these advanced cell lines, ensuring that you have the tools necessary to unravel genetic complexities and advance health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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