Gene: APOD
Official Full Name: apolipoprotein Dprovided by HGNC
Gene Summary: This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01024 | APOD Knockout cell line (HEK293) | Human | APOD | 1:3~1:6 | Negative | Online Inquiry |
KO38970 | APOD Knockout cell line (A549) | Human | APOD | 1:3~1:4 | Negative | Online Inquiry |
APOD Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disable the expression of the apolipoprotein D (APOD) gene, which plays a pivotal role in lipid metabolism and neuroprotection. By utilizing advanced CRISPR-Cas9 technology, these cell lines provide a reliable model for studying the functional consequences of APOD gene disruption and unraveling its involvement in various pathophysiological processes, including Alzheimer's disease, cancer progression, and metabolic disorders.
The functioning of APOD Gene Knockout Cell Lines hinges on the precise editing of the APOD gene locus, resulting in targeted gene inactivation. This allows researchers to observe phenotypic changes and assess the cellular behaviors that arise from the loss of APOD expression. This model is particularly crucial for investigating the underlying mechanisms of diseases where apolipoprotein D is implicated, supporting drug development and therapeutic interventions.
In terms of scientific significance, these knockout cell lines serve as invaluable tools in both basic and translational research settings. Their applications extend to studying neuronal health, cellular stress responses, and interactions in lipid transport, making them essential for elucidating disease mechanisms and validating potential drug targets.
One of the distinctive advantages of the APOD Gene Knockout Cell Lines is their high specificity and efficiency, minimizing off-target effects typical in traditional gene-editing approaches. Compared to other gene disruption methods, such as siRNA or plasmid-based systems, these cell lines provide a more stable and reproducible gene knockout, ensuring consistent experimental outcomes.
The value of APOD Gene Knockout Cell Lines to researchers and clinicians is undeniable. They offer a sophisticated platform to advance our understanding of lipid-related diseases and neurobiology while supporting innovative solutions in therapeutic development. Furthermore, they enable researchers to generate high-quality data, which is crucial for publishing impactful findings and advancing scientific knowledge.
Our company specializes in cutting-edge biotechnological solutions, and our APOD Gene Knockout Cell Lines exemplify our commitment to delivering high-quality research tools that empower scientific progress and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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