Gene: ANKRD13B
Official Full Name: ankyrin repeat domain 13Bprovided by HGNC
Gene Summary: Enables ubiquitin-modified protein reader activity. Involved in negative regulation of receptor internalization. Located in endosome; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27885 | ANKRD13B Knockout cell line (HeLa) | Human | ANKRD13B | 1:3~1:6 | Negative | Online Inquiry |
KO27886 | ANKRD13B Knockout cell line (HCT 116) | Human | ANKRD13B | 1:2~1:4 | Negative | Online Inquiry |
KO27887 | ANKRD13B Knockout cell line (HEK293) | Human | ANKRD13B | 1:3~1:6 | Negative | Online Inquiry |
KO27888 | ANKRD13B Knockout cell line (A549) | Human | ANKRD13B | 1:3~1:4 | Negative | Online Inquiry |
ANKRD13B Gene Knockout Cell Lines are engineered cellular models specifically designed to study the functional implications of the ANKRD13B gene, which encodes a protein involved in cellular processes such as endocytosis, intracellular trafficking, and protein sorting. These knockout cell lines are generated using CRISPR-Cas9 technology, leading to precise deletions in the ANKRD13B gene, effectively silencing its expression. This targeted gene editing approach allows for the exploration of the physiological and pathological roles of ANKRD13B in various cellular contexts.
The primary function of ANKRD13B is to mediate the endocytic sorting of proteins, playing a crucial role in receptor recycling and degradation pathways. By using ANKRD13B knockout cell lines, researchers can investigate the downstream effects of its absence, providing insights into mechanisms underlying diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. These models are invaluable for understanding how disruptions in trafficking pathways contribute to disease pathology.
Importantly, ANKRD13B Gene Knockout Cell Lines offer distinct advantages over conventional cell lines and models. They enable researchers to create a more accurate representation of the biological systems of interest, facilitating drug discovery and therapeutic development by allowing for the assessment of potential interventions targeting the ANKRD13B pathway. Additionally, these knockout lines can be employed in high-throughput screening assays to identify compounds that may restore normal cellular functions disrupted by ANKRD13B dysregulation.
For researchers and clinicians, the value of ANKRD13B Gene Knockout Cell Lines lies in their ability to provide a robust platform for dissecting complex cellular processes, testing hypotheses, and ultimately translating findings into clinical applications. With our company’s expertise in genomic technologies and commitment to advancing scientific research, we ensure that our products are of the highest quality, empowering scientists to advance their inquiries with confidence and precision.
Please note that all services are for research use only. Not intended for any clinical use.
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