Gene: ANK2
Official Full Name: ankyrin 2provided by HGNC
Gene Summary: This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04545 | ANK2 Knockout cell line (HCT 116) | Human | ANK2 | 1:2~1:4 | Negative | Online Inquiry |
KO04546 | ANK2 Knockout cell line (HEK293) | Human | ANK2 | 1:3~1:6 | Negative | Online Inquiry |
KO04547 | ANK2 Knockout cell line (A549) | Human | ANK2 | 1:3~1:4 | Negative | Online Inquiry |
ANK2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function of the ankyrin 2 gene (ANK2), which plays a crucial role in cell membrane stability and molecular signaling pathways. By employing advanced CRISPR/Cas9 gene-editing technology, these cell lines provide a powerful tool for selectively knocking out the ANK2 gene, thereby allowing researchers to investigate the downstream effects of its absence on cellular behavior and physiology.
The primary function of the ANK2 knockout cell lines is to enable detailed exploration of the ankyrin 2 protein's role within the cytoskeleton and its contributions to cellular processes such as ion channel localization, membrane integrity, and cell signaling. By analyzing the resultant phenotypic changes post-knockout, researchers can uncover insights into fundamental biological mechanisms, as well as the pathological relevance of ANK2 in various diseases, including cardiac disorders and neurodegenerative conditions.
The scientific importance of these cell lines cannot be overstated. They provide a reliable platform for assessing the molecular pathways associated with ankyrin 2 and have significant implications for drug discovery, genetic research, and the development of therapeutic interventions. In clinical settings, a clearer understanding of ANK2-associated molecular dysfunctions could lead to the identification of novel biomarkers and therapeutic targets.
When compared to conventional gene silencing methods or other knockout systems, ANK2 Gene Knockout Cell Lines offer several distinct advantages. They facilitate precise gene editing with minimal off-target effects, ensuring greater experimental reproducibility. Additionally, they are readily available and can be customized for different research applications, which enhances their utility in diverse study contexts.
For researchers and clinicians alike, these cell lines represent an invaluable resource for advancing our understanding of ankyrin 2 biology and its profound implications in human health and disease. Our company is committed to providing top-tier genetic tools for the scientific community, leveraging our expertise in cell line development to deliver products that empower researchers to break new ground in their explorations.
Please note that all services are for research use only. Not intended for any clinical use.
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