Gene: AMTN
Official Full Name: amelotinprovided by HGNC
Gene Summary: The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21378 | AMTN Knockout cell line (HeLa) | Human | AMTN | 1:3~1:6 | Negative | Online Inquiry |
AMTN Gene Knockout Cell Lines are specialized cellular models created through precise genetic engineering techniques to remove or "knockout" the AMTN gene, which encodes the amelotin protein predominantly expressed in the enamel of teeth. This innovative product provides exceptional insights into the functions of the AMTN gene in mineralization processes and enamel formation, making it a valuable tool for researchers exploring dental biology, genetics, and enamel-related disorders.
The key function of these cell lines is to facilitate the investigation of the biological roles of amelotin in enamel matrix maturation and regulation. By removing the AMTN gene, the cell lines allow researchers to observe cellular phenotypic alterations and elucidate the molecular pathways influenced by amelotin. This can lead to a deeper understanding of enamel diseases, including caries and developmental disorders, ultimately contributing to advancements in dental therapeutics.
The scientific importance of AMTN Gene Knockout Cell Lines extends into both research and clinical applications. Researchers can use these models to study gene function, engage in drug screening, and identify potential therapeutic targets for enamel regeneration. In clinical settings, findings derived from these models can pave the way for innovative treatments that address enamel defects and improve oral health outcomes.
When compared to alternative models, AMTN Gene Knockout Cell Lines offer several distinctive advantages. They provide a precise and reproducible system for studying gene function in a controlled environment, reducing variability often seen in traditional models. Additionally, their design aligns with contemporary gene-editing methodologies, ensuring compatibility with cutting-edge research techniques.
In summary, AMTN Gene Knockout Cell Lines represent a crucial innovation in the field of dental biology. They empower researchers and clinicians alike to explore the complexities of enamel formation and pathology with unprecedented clarity, enabling new avenues for understanding and treatment of dental issues. Our company is dedicated to advancing the field of biological research by providing high-quality, specialized products that meet the needs of the scientific community, underscoring our commitment to innovation and excellence in biological products.
Please note that all services are for research use only. Not intended for any clinical use.
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