Home / AMPD3 Knockout Cell Lines

AMPD3 Knockout Cell Lines

Gene: AMPD3

Official Full Name: adenosine monophosphate deaminase 3provided by HGNC

Gene Summary: This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate catabolic pathway. This gene encodes the erythrocyte (E) isoforms, whereas other family members encode isoforms that predominate in muscle (M) and liver (L) cells. Mutations in this gene lead to the clinically asymptomatic, autosomal recessive condition erythrocyte AMP deaminase deficiency. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39010 AMPD3 Knockout cell line (HeLa) Human AMPD3 1:3~1:6 Negative Online Inquiry
KO39011 AMPD3 Knockout cell line (HCT 116) Human AMPD3 1:2~1:4 Negative Online Inquiry
KO39012 AMPD3 Knockout cell line (A549) Human AMPD3 1:3~1:4 Negative Online Inquiry

Background

AMPD3 Gene Knockout Cell Lines refer to a unique set of genetically modified cell lines designed to study the function of the AMP Deaminase 3 (AMPD3) gene. These cell lines have undergone precise genetic modification to inactivate the AMPD3 gene, allowing researchers to observe the resultant phenotypic and biochemical changes. AMPD3 plays a critical role in the purine nucleotide metabolism pathway, particularly in catalyzing the deamination of AMP to IMP. By knocking out this gene, researchers can investigate its involvement in various metabolic disorders, cancer biology, and cellular signaling mechanisms.

The key function of AMPD3 knockout cell lines lies in their ability to elucidate the metabolic alterations that arise from diminished AMPD3 activity. This can manifest as significant changes in cellular energy homeostasis, nucleotide availability, and overall cellular metabolism, opening pathways for exploring therapeutic targets in conditions such as diabetes, cardiac hypertrophy, and ischemic injury. In research contexts, these cell lines serve as invaluable tools for drug development, enabling the assessment of potential therapeutic compounds aimed at restoring normal metabolic function.

One of the standout advantages of using AMPD3 Gene Knockout Cell Lines is their specificity and reliability. Compared to traditional approaches, which may involve non-specific inhibitors or rudimentary animal models, these cell lines provide a controlled environment to study the direct effects of AMPD3 gene inactivation. This specificity translates into more reproducible and interpretable results, ultimately facilitating faster advancements in understanding complex biological processes.

The value of AMPD3 Gene Knockout Cell Lines extends beyond basic research; they have critical applications in clinical settings, particularly in personalized medicine. By identifying the biological effects of AMPD3 deficiency, researchers can tailor approaches for managing metabolic diseases associated with dysfunction in nucleotide metabolism.

Our company is dedicated to advancing scientific inquiry through high-quality biological products, including AMPD3 Gene Knockout Cell Lines. We leverage cutting-edge technologies and stringent quality control measures to ensure that our products empower researchers and clinicians in their quest for actionable insights and innovative solutions.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.