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ALKBH4 Knockout Cell Lines

Gene: ALKBH4

Official Full Name: alkB homolog 4, lysine demethylaseprovided by HGNC

Gene Summary: Enables 2-oxoglutarate-dependent dioxygenase activity and actin binding activity. Involved in actomyosin structure organization and cleavage furrow ingression. Located in contractile ring and midbody. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19886 ALKBH4 Knockout cell line (HeLa) Human ALKBH4 1:3~1:6 Negative Online Inquiry
KO19887 ALKBH4 Knockout cell line (HCT 116) Human ALKBH4 1:2~1:4 Negative Online Inquiry
KO19888 ALKBH4 Knockout cell line (HEK293) Human ALKBH4 1:3~1:6 Negative Online Inquiry
KO19889 ALKBH4 Knockout cell line (A549) Human ALKBH4 1:3~1:4 Negative Online Inquiry

Background

ALKBH4 Gene Knockout Cell Lines are biologically engineered cell lines designed to inhibit the expression of the ALKBH4 gene, a member of the ALKB family of dioxygenases. This gene is implicated in various cellular processes, including RNA demethylation, a crucial post-transcriptional modification necessary for gene regulation and cell differentiation. By employing CRISPR-Cas9 technology, these knockout cell lines provide a valuable resource for investigating the functional roles of ALKBH4 in cellular metabolism, stress response, and oncogenesis.

The primary mechanism of ALKBH4 knockout involves the introduction of targeted mutations in the gene’s coding sequence. This leads to a complete loss of gene function, thereby enabling researchers to elucidate the pathways and molecular mechanisms influenced by ALKBH4. In both research and clinical settings, these cell lines are vital for studying the gene’s roles in diseases such as cancer, neurodegeneration, and metabolic disorders. Their use in high-throughput screening and mechanistic studies can unveil new therapeutic targets and biomarkers.

One significant advantage of our ALKBH4 Gene Knockout Cell Lines is their reproducibility and reliability, validated through extensive characterization. Unlike conventional knockdown approaches, which may retain partial gene function, our knockout lines ensure a complete and permanent disruption of ALKBH4, providing clearer insights into gene function. Additionally, these cell lines are compatible with various host systems, allowing for broader applications across different research contexts.

For researchers and clinicians alike, our ALKBH4 Gene Knockout Cell Lines represent a powerful tool for unraveling the complexities of gene function and disease. With our commitment to quality and innovation in biological products, our offerings empower the scientific community to push the boundaries of discovery in molecular biology and therapeutic development. With years of expertise, we ensure that our products meet the highest standards, supporting your research objectives effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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