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ALDH3A1 Knockout Cell Lines

Gene: ALDH3A1

Official Full Name: aldehyde dehydrogenase 3 family member A1provided by HGNC

Gene Summary: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02960 ALDH3A1 Knockout cell line (HeLa) Human ALDH3A1 1:3~1:6 Negative Online Inquiry
KO02961 ALDH3A1 Knockout cell line (HCT 116) Human ALDH3A1 1:2~1:4 Negative Online Inquiry
KO02962 ALDH3A1 Knockout cell line (HEK293) Human ALDH3A1 1:3~1:6 Negative Online Inquiry
KO02963 ALDH3A1 Knockout cell line (A549) Human ALDH3A1 1:3~1:4 Negative Online Inquiry

Background

ALDH3A1 Gene Knockout Cell Lines are specialized cell lines engineered to lacking the ALDH3A1 gene, which encodes the enzyme aldehyde dehydrogenase 3A1. This enzyme is primarily involved in detoxifying aldehydes and is implicated in various biological processes, including cellular metabolism and oxidative stress response. By specifically knocking out this gene, researchers can investigate the role of ALDH3A1 in both healthy and disease states, enabling deeper insights into its functions and contributions in cellular biology.

The key functionality of the ALDH3A1 knockout cell lines lies in their ability to mimic pathological conditions that may arise from ALDH3A1 deficiency. This is particularly relevant in cancer research, where altered aldehyde metabolism can affect tumorigenesis and therapeutic responses. By studying these knockout lines, researchers can elucidate the biochemical pathways associated with dysfunctional ALDH activity and identify potential therapeutic targets for selective intervention.

The scientific importance of these cell lines is underscored by their applications in drug development and disease modeling. In clinical research, they can be utilized to screen for potential chemotherapeutic agents that exploit the metabolic vulnerabilities linked to ALDH3A1 deficiency, thereby advancing precision medicine approaches. Additionally, they serve as valuable tools in pharmacokinetic studies, enabling the assessment of drug metabolism and efficacy.

Compared to alternative cell models, ALDH3A1 Gene Knockout Cell Lines offer a unique advantage by providing a controlled background free from ALDH3A1 activity, facilitating a clearer interpretation of experimental outcomes. This specificity increases the robustness of data obtained, making it easier for researchers to draw meaningful conclusions.

For researchers and clinicians, the value of the ALDH3A1 Gene Knockout Cell Lines is evident in their capability to accelerate the understanding of metabolic disorders and cancer biology. As the demand for tailored therapeutic strategies grows, these cell lines represent a critical resource for uncovering novel insights into ALDH3A1-related pathways.

Our company prides itself on providing high-quality, precisely engineered cell lines, leveraging cutting-edge technology to support the scientific community in their quest for innovation and discovery. We are committed to advancing research and offer exceptional expertise in the development of unique biological research tools, ensuring our customers' needs are met with precision and excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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