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ALDH1L2 Knockout Cell Lines

Gene: ALDH1L2

Official Full Name: aldehyde dehydrogenase 1 family member L2provided by HGNC

Gene Summary: This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19901 ALDH1L2 Knockout cell line (HeLa) Human ALDH1L2 1:3~1:6 Negative Online Inquiry
KO19902 ALDH1L2 Knockout cell line (A549) Human ALDH1L2 1:3~1:4 Negative Online Inquiry

Background

ALDH1L2 Gene Knockout Cell Lines are a specialized set of genetically modified cell lines designed to specifically inhibit the expression of the ALDH1L2 gene, which is involved in critical metabolic pathways such as folate metabolism and one-carbon metabolism. These cell lines serve as indispensable tools for researchers aiming to unravel the multifaceted roles of ALDH1L2 in cellular processes, development, and disease pathology.

The primary mechanism by which ALDH1L2 knockout cell lines operate is through the targeted disruption of the ALDH1L2 gene via techniques such as CRISPR-Cas9 gene editing. This knockout effectively eliminates the gene's function, allowing researchers to directly observe the phenotypic and biochemical consequences of its absence. By facilitating studies that capitalize on the disruption of ALDH1L2, these cell lines enable detailed investigations into metabolic dysregulations associated with various conditions, including cancer and neurodegenerative diseases.

The scientific importance of ALDH1L2 gene knockout cell lines cannot be overstated, as they provide unique insights into the role of folate and one-carbon metabolism in health and disease. Their applications span biochemical assays, drug screening, and the development of therapeutic strategies targeting metabolic disorders. In clinical research environments, such models may assist in identifying potential biomarker targets for precision medicine approaches and therapeutics.

Unlike traditional knockout methods, the ALDH1L2 cell lines offer specificity, reproducibility, and are amenable to high-throughput screening, making them an ideal choice for modern biomedical research. Their unique selling points include optimized performance in relevant biological assays and robust customer support, ensuring researchers can obtain meaningful and reliable data.

For researchers and clinicians alike, the value of ALDH1L2 Gene Knockout Cell Lines extends beyond mere genetic manipulation; they are key enablers of discovery in the ever-evolving landscape of metabolic research. Our company is dedicated to providing high-quality biological products and has extensive expertise in genetic engineering, ensuring that you receive reliable and cutting-edge tools to advance your research initiatives.

Please note that all services are for research use only. Not intended for any clinical use.

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