Gene: ALCAM
Official Full Name: activated leukocyte cell adhesion moleculeprovided by HGNC
Gene Summary: This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09954 | ALCAM Knockout cell line (HeLa) | Human | ALCAM | 1:3~1:6 | Negative | Online Inquiry |
KO09955 | ALCAM Knockout cell line (HCT 116) | Human | ALCAM | 1:2~1:4 | Negative | Online Inquiry |
KO09956 | ALCAM Knockout cell line (HEK293) | Human | ALCAM | 1:3~1:6 | Negative | Online Inquiry |
KO09957 | ALCAM Knockout cell line (A549) | Human | ALCAM | 1:3~1:4 | Negative | Online Inquiry |
ALCAM Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the expression of the ALCAM (Activated Leukocyte Cell Adhesion Molecule) gene. This innovative product enables researchers to investigate the functional implications of ALCAM in diverse biological processes, including cell adhesion, immune response modulation, and cancer metastasis. By employing CRISPR/Cas9 or other gene-editing technologies, these cell lines serve as invaluable tools for elucidating the role of ALCAM in various physiological and pathological conditions.
The primary function of ALCAM Gene Knockout Cell Lines lies in their ability to mimic disease states devoid of ALCAM, allowing researchers to dissect its involvement in cell signaling pathways and interactions with neighboring cells. This is particularly significant for studies focusing on immune system behavior, tumor microenvironments, and neurobiology, as ALCAM has been implicated in multiple disease processes including cancer and autoimmune disorders.
In terms of scientific importance, ALCAM Gene Knockout Cell Lines enhance our understanding of cell adhesion mechanisms, contributing to the development of targeted therapies and diagnostic tools. Researchers can utilize these models to validate hypotheses, screen for potential drug candidates, and investigate therapeutic strategies aimed at modulating ALCAM functionality.
What sets ALCAM Gene Knockout Cell Lines apart from other genetic models is the precision and consistency achieved through advanced gene-editing techniques. Compared to traditional knockout methods, our cell lines demonstrate enhanced stability and reproducibility, ensuring that results are reliable and translatable to clinical contexts. Furthermore, these models are compatible with a wide array of assays, including proliferation, migration, and interaction studies, making them versatile tools in the lab.
The value of ALCAM Gene Knockout Cell Lines to researchers and clinicians is profound; they empower scientific inquiry into the complexities of cell adhesion and communication, potentially leading to novel interventions for diseases heavily influenced by ALCAM dynamics.
With extensive expertise in gene editing technologies and a commitment to advancing biomedical research, our company stands at the forefront of providing high-quality biological products, ensuring that our clients have access to cutting-edge tools that drive scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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