Gene: AKT1S1
Official Full Name: AKT1 substrate 1provided by HGNC
Gene Summary: AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09166 | AKT1S1 Knockout cell line (HeLa) | Human | AKT1S1 | 1:3~1:6 | Negative | Online Inquiry |
KO09167 | AKT1S1 Knockout cell line (HCT 116) | Human | AKT1S1 | 1:2~1:4 | Negative | Online Inquiry |
KO09168 | AKT1S1 Knockout cell line (HEK293) | Human | AKT1S1 | 1:3~1:6 | Negative | Online Inquiry |
KO09169 | AKT1S1 Knockout cell line (A549) | Human | AKT1S1 | 1:3~1:4 | Negative | Online Inquiry |
AKT1S1 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to lack the AKT1S1 gene, which encodes a vital regulatory protein involved in the AKT signaling pathway. This pathway plays a crucial role in various cellular processes such as metabolism, growth, and survival. By removing the AKT1S1 gene, these knockout cell lines provide a robust model for studying the intricate mechanisms of AKT signaling and its implications in disease processes, particularly in cancer and metabolic disorders.
The primary function of AKT1S1 involves the regulation of mTOR signaling pathways, which are essential for cellular growth and homeostasis. Consequently, by using these knockout cell lines, researchers can dissect the individual contributions of AKT1S1 in cellular signaling, as well as observe the downstream effects on cell proliferation and apoptosis. This enables a better understanding of the pathway's role in various pathological conditions, thereby driving innovation in therapeutic strategies.
From a scientific standpoint, AKT1S1 Gene Knockout Cell Lines are invaluable in both academic and clinical research. They offer insights into how aberrant signaling can lead to diseases, while also serving as potential platforms for drug discovery and development. Researchers can utilize these cell lines to evaluate the efficacy and mechanism of new anti-cancer compounds or metabolic agents, seamlessly integrating findings into translational research.
What sets AKT1S1 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability for studying the AKT pathway. Many existing models may exhibit variable expression levels or compensatory mechanisms that distort research outcomes. In contrast, these knockout lines provide a more consistent and biologically relevant system that researchers can trust.
For researchers and clinicians focused on understanding cellular signaling and developing targeted therapies, the AKT1S1 Gene Knockout Cell Lines offer a unique advantage in achieving reliable, reproducible results. Our company prides itself on its commitment to precision in genetic engineering, ensuring that our products meet the highest standards and support scientific discovery. Our portfolio of biological products is designed to empower researchers with the tools necessary for advancing knowledge and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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