Gene: AKR7L
Official Full Name: aldo-keto reductase family 7 like (gene/pseudogene)provided by HGNC
Gene Summary: This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21500 | AKR7L Knockout cell line (HeLa) | Human | AKR7L | 1:3~1:6 | Negative | Online Inquiry |
KO21501 | AKR7L Knockout cell line (HCT 116) | Human | AKR7L | 1:2~1:4 | Negative | Online Inquiry |
KO21502 | AKR7L Knockout cell line (HEK293) | Human | AKR7L | 1:3~1:6 | Negative | Online Inquiry |
KO21503 | AKR7L Knockout cell line (A549) | Human | AKR7L | 1:3~1:4 | Negative | Online Inquiry |
AKR7L Gene Knockout Cell Lines are precisely engineered cellular models created to study the functional role of the AKR7L gene within various biological contexts. These cell lines are generated through advanced gene editing techniques, specifically CRISPR-Cas9, leading to a complete knockout of the AKR7L gene, thus enabling researchers to investigate the gene's contributions to cellular processes, metabolic pathways, and disease mechanisms.
The primary function of AKR7L Gene Knockout Cell Lines lies in their ability to mimic altered gene expression profiles, providing insights into how the absence of AKR7L affects cellular behavior, signaling pathways, and overall physiology. By eliminating the function of this gene, researchers can elucidate its role in conditions such as cancer, metabolic disorders, and other pathologies, unraveling potential therapeutic targets and biomarkers.
The scientific importance of these knockout models cannot be overstated. They serve as invaluable tools in both research and clinical settings, facilitating drug discovery, toxicity testing, and the understanding of gene-environment interactions. They also provide a platform for high-throughput screening of compounds that may modulate biological responses governed by the AKR7L pathway.
In comparison to conventional cell lines, which may possess functional AKR7L expression, using knockout models offers a distinct advantage by allowing for clearer interpretation of results without confounding signals from residual gene activity. This specificity enhances experimental reproducibility and scientific validity.
For researchers and clinicians, AKR7L Gene Knockout Cell Lines represent a powerful asset for advancing our understanding of gene function, improving disease models, and exploring novel therapeutic strategies. By utilizing this product, users can significantly enhance the quality and impact of their research findings.
Our company is committed to excellence in biotechnology, leveraging state-of-the-art methodologies and deep scientific expertise to provide researchers with innovative tools like the AKR7L Gene Knockout Cell Lines, tailored to drive scientific discovery and improve human health.
Please note that all services are for research use only. Not intended for any clinical use.
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