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AKAP11 Knockout Cell Lines

Gene: AKAP11

Official Full Name: A-kinase anchoring protein 11provided by HGNC

Gene Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01826 AKAP11 Knockout cell line (HeLa) Human AKAP11 1:3~1:6 Negative Online Inquiry
KO01827 AKAP11 Knockout cell line (HCT 116) Human AKAP11 1:2~1:4 Negative Online Inquiry
KO01828 AKAP11 Knockout cell line (HEK293) Human AKAP11 1:3~1:6 Negative Online Inquiry
KO01829 AKAP11 Knockout cell line (A549) Human AKAP11 1:3~1:4 Negative Online Inquiry

Background

AKAP11 Gene Knockout Cell Lines represent a significant advancement in molecular biology, specifically designed to facilitate the study of the A-kinase anchoring protein 11 (AKAP11) and its associated signaling pathways. These specialized cell lines have undergone precise genetic modifications that disrupt the functionality of the AKAP11 gene, allowing researchers to investigate its role in cellular processes such as signal transduction, cellular organization, and gene expression regulation.

The primary function of AKAP11 involves its ability to localize protein kinase A (PKA) to specific subcellular compartments, thereby ensuring that PKA exerts its effects on particular targets at the right time and place within the cell. By utilizing the AKAP11 Gene Knockout Cell Lines, scientists can discern the consequences of AKAP11 deletion on various cellular activities, including metabolism, cell cycle regulation, and stress responses. This provides invaluable insights into the fundamental biology of cell signaling and its implications in disease mechanisms.

The scientific importance of these cell lines extends into both research and clinical applications. In research settings, they are essential for elucidating the complex interactions between intracellular signaling molecules and their contributions to diseases, including cancer and cardiovascular disorders. Clinically, understanding the functions of AKAP11 can aid in the development of targeted therapies that exploit its role in disease processes.

What sets our AKAP11 Gene Knockout Cell Lines apart from alternatives is the precision and quality of the genetic knockout achieved, supported by robust validation techniques, such as CRISPR/Cas9 methodologies. Additionally, our cell lines are readily available and characterized for consistent performance, ensuring that researchers can achieve reproducible results and save significant time during their experiments.

By choosing AKAP11 Gene Knockout Cell Lines, researchers and clinicians gain access to a valuable tool that enhances their ability to dissect complex biological questions with accuracy. Our commitment to high-quality biological products is backed by extensive expertise in genetic engineering and molecular biology. We strive to support the scientific community with innovative solutions that advance research and improve therapeutic outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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