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AK2 Knockout Cell Lines

Gene: AK2

Official Full Name: adenylate kinase 2provided by HGNC

Gene Summary: Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04741 AK2 Knockout cell line (HeLa) Human AK2 1:3~1:6 Negative Online Inquiry
KO04742 AK2 Knockout cell line (HCT 116) Human AK2 1:2~1:4 Negative Online Inquiry
KO04743 AK2 Knockout cell line (HEK293) Human AK2 1:3~1:6 Negative Online Inquiry
KO04744 AK2 Knockout cell line (A549) Human AK2 1:3~1:4 Negative Online Inquiry

Background

AK2 Gene Knockout Cell Lines are advanced cellular models generated through precision gene editing technologies, specifically designed to facilitate the study of the adenosine kinase (AK2) gene's function. These cell lines provide researchers with a valuable tool to explore the molecular pathways influenced by AK2, a key player in cellular energy metabolism and signaling. The knockout mechanism involves the targeted deletion of the AK2 gene, allowing scientists to observe the resultant phenotypic changes in various biological processes, including cellular proliferation, apoptosis, and metabolic regulation.

The key functions of the AK2 Gene Knockout Cell Lines lie in their ability to mimic relevant disease states. By eliminating the AK2 gene's expression, researchers can investigate the functional consequences of its absence in controlled experimental settings. This makes them particularly useful in dissecting the roles of AK2 in conditions such as cancer and metabolic disorders, where aberrations in energy metabolism can drive pathophysiological outcomes.

Scientifically, these cell lines are important for both basic and applied research, including drug development and therapeutic interventions. The AK2 knockout models can serve as platforms for screening potential pharmacological agents, and understanding the underlying mechanisms of drug resistance or sensitivity in tumors, ultimately guiding clinicians in personalizing patient treatment strategies.

In comparison to other gene knockout tools, AK2 Gene Knockout Cell Lines stand out due to their high specificity and reliability, resulting from cutting-edge CRISPR/Cas9 technologies that minimize off-target effects. Furthermore, the cell lines can be provided in various cellular backgrounds, enhancing their applicability across multiple experimental contexts.

For researchers and clinicians alike, AK2 Gene Knockout Cell Lines represent a significant advancement, equipping them with the necessary tools to uncover novel insights into molecular mechanisms and drive innovation in therapeutic discoveries. Our company specializes in producing high-quality biological models, ensuring that our offerings support the advancement of scientific knowledge and clinical breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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