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AHRR Knockout Cell Lines

Gene: AHRR

Official Full Name: aryl hydrocarbon receptor repressorprovided by HGNC

Gene Summary: The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20961 AHRR Knockout cell line (HeLa) Human AHRR 1:3~1:6 Negative Online Inquiry
KO20962 AHRR Knockout cell line (HCT 116) Human AHRR 1:2~1:4 Negative Online Inquiry
KO20963 AHRR Knockout cell line (HEK293) Human AHRR 1:3~1:6 Negative Online Inquiry
KO20964 AHRR Knockout cell line (A549) Human AHRR 1:3~1:4 Negative Online Inquiry

Background

AHRR Gene Knockout Cell Lines represent a specific strain of genetically modified cells in which the aryl hydrocarbon receptor repressor (AHRR) gene has been inactivated. AHRR is a key regulator of the aryl hydrocarbon receptor (AHR) pathway, which is known to play significant roles in cellular processes such as xenobiotic metabolism, immune response, and cell proliferation. The knockout of this gene allows researchers to study the function of AHR in various biological contexts, including its involvement in cancer, metabolic disorders, and environmental toxicity.

By utilizing CRISPR/Cas9 technology for precise genomic editing, these cell lines enable the investigation of AHR-mediated signaling pathways with enhanced specificity and reduced off-target effects. The AHR pathway is implicated in the response to environmental pollutants and plays a substantial role in mediating the effects of dietary compounds, thus making these knockout cell lines a valuable tool for toxicology studies, pharmacological research, and development of therapeutic agents targeting AHR.

One of the significant advantages of AHRR Gene Knockout Cell Lines is their ability to facilitate high-throughput screening in both basic and applied research settings, providing insights into AHR function under controlled conditions. Moreover, compared to traditional models, these knockout systems offer streamlined methodologies, decreasing ambiguity in experimental results and promoting reproducibility.

Researchers and clinicians can leverage these unique cell lines to accelerate their understanding of AHR signaling and its implications for human health and disease. Our expertise in genetic engineering and commitment to high-quality biological products ensure that every AHRR Gene Knockout Cell Line we provide meets rigorous standards for performance and reliability. With a focus on innovation and scientific integrity, we are dedicated to equipping the research community with cutting-edge tools that advance the frontiers of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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