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AGPS Knockout Cell Lines

Gene: AGPS

Official Full Name: alkylglycerone phosphate synthaseprovided by HGNC

Gene Summary: This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34077 AGPS Knockout cell line (HeLa) Human AGPS 1:3~1:6 Negative Online Inquiry
KO34078 AGPS Knockout cell line (HCT 116) Human AGPS 1:2~1:4 Negative Online Inquiry
KO34079 AGPS Knockout cell line (HEK293) Human AGPS 1:3~1:6 Negative Online Inquiry
KO34080 AGPS Knockout cell line (A549) Human AGPS 1:3~1:4 Negative Online Inquiry

Background

AGPS Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of gene function by providing a controlled environment to observe the effects of gene deletion. These cell lines have been meticulously designed to lack the AGPS gene, which encodes the enzyme acylglycerol-3-phosphate acyltransferase, a critical component in lipid metabolism. The absence of this gene allows researchers to investigate the biochemical, physiological, and pathological roles of lipid biosynthesis and its implications in various diseases, including metabolic disorders and certain types of cancer.

The key mechanism by which AGPS Gene Knockout Cell Lines operate is through the targeted disruption of the AGPS gene using CRISPR/Cas9 technology. This advanced genome-editing technique ensures precise modifications, leading to a stable and reproducible knockout of the AGPS gene. Researchers can thus observe alterations in lipid composition, cellular signaling pathways, and energy metabolism, which are invaluable for understanding the role of lipids in cellular health and disease.

The scientific importance of these cell lines extends to their applications in both basic research and clinical studies. They serve as robust platforms for drug discovery, enabling the evaluation of potential therapeutics that target lipid metabolism. Additionally, they are instrumental in elucidating the mechanisms underlying diseases related to lipid dysregulation, such as obesity, diabetes, and cardiovascular diseases.

One of the distinct advantages of AGPS Gene Knockout Cell Lines is their specificity and reliability, which provides a significant improvement over traditional models that may have confounding variables. The controlled knockout allows for clearer interpretations of experimental results, fostering innovation and discovery in areas such as pharmacology and metabolomics.

For researchers and clinicians seeking high-quality, precise tools for gene function studies and therapeutic exploration, AGPS Gene Knockout Cell Lines represent a pivotal resource. Their ability to contribute to significant advancements in our understanding of lipid metabolism makes them an essential addition to any laboratory's repertoire.

Our company, known for its expertise in genetic engineering and cellular biology, is committed to providing top-tier biological products that enhance research capabilities and facilitate groundbreaking discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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