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AGO3 Knockout Cell Lines

Gene: AGO3

Official Full Name: argonaute RISC catalytic component 3provided by HGNC

Gene Summary: This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03993 AGO3 Knockout cell line (HeLa) Human AGO3 1:3~1:6 Negative Online Inquiry
KO03994 AGO3 Knockout cell line (HCT 116) Human AGO3 1:2~1:4 Negative Online Inquiry
KO03995 AGO3 Knockout cell line (HEK293) Human AGO3 1:3~1:6 Negative Online Inquiry
KO03996 AGO3 Knockout cell line (A549) Human AGO3 1:3~1:4 Negative Online Inquiry

Background

AGO3 Gene Knockout Cell Lines represent a crucial advancement in molecular biology, specifically designed to facilitate the study of gene function and regulation within the context of cellular mechanisms. These cell lines are generated by targeted gene editing techniques, such as CRISPR/Cas9, to create precise deletions in the AGO3 gene, which is a vital component of the RNA-induced silencing complex and plays a significant role in post-transcriptional gene regulation. This knockout allows researchers to investigate the downstream effects on gene expression and cellular pathways, providing insights into the complexity of gene interactions and regulatory networks.

The key mechanism underlying the utility of AGO3 Gene Knockout Cell Lines lies in their inherent ability to mimic phenotypic changes associated with gene loss. By disrupting the AGO3 gene, researchers can explore its role in various biological processes such as microRNA-mediated gene silencing and its implications in diseases including cancer and viral infections. This product is particularly valuable for developing therapeutic strategies and understanding resistance mechanisms in oncology and virology research.

Compared to traditional methods of gene silencing, like RNA interference, the AGO3 Gene Knockout Cell Lines offer a more stable and permanent alteration, which minimizes off-target effects and enhances reproducibility in experimental results. This permanence allows for prolonged studies of gene function over time, which is vital for dissecting complex biological responses.

The value of AGO3 Gene Knockout Cell Lines to researchers and clinicians cannot be overstated; they provide a powerful tool for elucidating the functions of critical genes, leading to vital discoveries in molecular biology and potential therapeutic applications. Furthermore, the ability to use these lines in high-throughput screening processes makes them indispensable for drug development and testing.

Our company is committed to empowering scientific discovery by offering high-quality biological products and expertise. With a focus on innovation and precision, we support researchers in their quest to unlock the complexities of gene regulation and its implications in human health.

Please note that all services are for research use only. Not intended for any clinical use.

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