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ADGRE2 Knockout Cell Lines

Gene: ADGRE2

Official Full Name: adhesion G protein-coupled receptor E2provided by HGNC

Gene Summary: This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26750 ADGRE2 Knockout cell line (HeLa) Human ADGRE2 1:3~1:6 Negative Online Inquiry
KO26751 ADGRE2 Knockout cell line (HCT 116) Human ADGRE2 1:2~1:4 Negative Online Inquiry

Background

ADGRE2 Gene Knockout Cell Lines are engineered cellular models designed for the specific loss of function of the ADGRE2 gene, which encodes for the adhesion G-protein-coupled receptor E2 (ADGRE2). These cell lines serve as invaluable tools for understanding the biological functions of ADGRE2 in various physiological and pathological contexts, particularly in immune responses, inflammation, and tumorigenesis.

The ADGRE2 gene plays a crucial role in cell adhesion and migration, primarily influencing cellular interactions within the immune system. By creating knockout cell lines, researchers can precisely observe the effects of ADGRE2 deficiency, elucidating its contributions to cellular signaling pathways and its implications in diseases. The mechanisms of action within these models involve the disruption of cellular adhesion dynamics, which can provide insights into how the absence of ADGRE2 may lead to altered inflammatory outcomes and cancer progression.

In both research and clinical settings, these knockout cell lines are significant due to their potential to facilitate the development of novel therapeutic strategies targeting ADGRE2-associated diseases. The ability to mimic specific pathological conditions allows for targeted drug development and helps identify biomarkers for disease prognosis.

What sets our ADGRE2 Gene Knockout Cell Lines apart from alternatives is our commitment to precision engineering and rigorous validation. Our products undergo extensive characterization, ensuring high reproducibility in experimental results. Additionally, we offer customization options to cater to various experimental needs, enhancing versatility in application.

By choosing our ADGRE2 Gene Knockout Cell Lines, researchers and clinicians gain access to a reliable model for exploring the complex roles of ADGRE2 in human biology. Ultimately, our product is designed to empower scientific discovery and translation into clinical innovations, reflecting our expertise in developing advanced biological models to support groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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