Gene: ADAMTS15
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 15provided by HGNC
Gene Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20726 | ADAMTS15 Knockout cell line (HeLa) | Human | ADAMTS15 | 1:3~1:6 | Negative | Online Inquiry |
KO20727 | ADAMTS15 Knockout cell line (HEK293) | Human | ADAMTS15 | 1:3~1:6 | Negative | Online Inquiry |
KO20728 | ADAMTS15 Knockout cell line (A549) | Human | ADAMTS15 | 1:3~1:4 | Negative | Online Inquiry |
ADAMTS15 Gene Knockout Cell Lines are specialized cellular models where the ADAMTS15 gene has been effectively disrupted, allowing researchers to study the biological implications of its loss of function. This gene encodes a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family, known to play a critical role in extracellular matrix remodeling and modulation of inflammation. By employing CRISPR-Cas9 technology for precise gene editing, these knockout cell lines provide researchers with a robust tool for investigating the specific pathways influenced by ADAMTS15.
The key functions of the ADAMTS15 protein include cleavage of various extracellular matrix components and interactions with growth factors, which are crucial for multiple physiological processes, including tissue repair and inflammation. Knockout of this gene enables the exploration of its contribution to diseases such as cancer, arthritis, and other inflammatory conditions. By utilizing these cell lines, scientists can gather insights into the gene’s role in cellular behavior, signaling pathways, and how its absence affects overall cellular dynamics.
The significance of ADAMTS15 Gene Knockout Cell Lines extends to both basic research and clinical applications. They serve as vital models for understanding disease mechanisms and developing targeted therapies. This product stands out against alternatives due to its reliability in replicating the absence of gene function, availability of well-characterized cellular backgrounds, and support for high-throughput screening, making them ideal for drug discovery and validation studies.
The value of ADAMTS15 Gene Knockout Cell Lines to researchers and clinicians lies in their unique ability to provide insights into gene function and the molecular underpinnings of diseases, enhancing translational research efforts. By facilitating an in-depth understanding of ADAMTS15, these cell lines can help drive innovations in therapeutic development.
At [Company Name], we pride ourselves on our extensive expertise in gene editing technologies and our commitment to supporting cutting-edge research through high-quality biological products. Our ADAMTS15 Gene Knockout Cell Lines are crafted in alignment with our mission to empower scientific discovery and therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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