Gene: ACTR1B
Official Full Name: actin related protein 1Bprovided by HGNC
Gene Summary: This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32272 | ACTR1B Knockout cell line (HeLa) | Human | ACTR1B | 1:3~1:6 | Negative | Online Inquiry |
KO32273 | ACTR1B Knockout cell line (HCT 116) | Human | ACTR1B | 1:2~1:4 | Negative | Online Inquiry |
KO32274 | ACTR1B Knockout cell line (HEK293) | Human | ACTR1B | 1:3~1:6 | Negative | Online Inquiry |
KO32275 | ACTR1B Knockout cell line (A549) | Human | ACTR1B | 1:3~1:4 | Negative | Online Inquiry |
ACTR1B Gene Knockout Cell Lines are genetically modified cell lines in which the ACTR1B gene has been selectively disrupted using advanced CRISPR technology. These cell lines serve as an invaluable tool for researchers investigating the roles of the ACTR1B gene, which encodes a key component of the dynactin complex critical for intracellular transport, cell division, and organelle positioning.
The primary function of these knockout cell lines is to facilitate in-depth studies of the functional impact and biological pathways modulated by ACTR1B deficiency. Through the targeted deletion of the ACTR1B gene, researchers can examine alterations in cellular processes such as mitosis, endocytosis, and neuronal development. This system allows for the assessment of phenotypic changes, cellular signaling, and the interaction of ACTR1B with other cytoskeletal proteins, thereby enhancing our understanding of various pathophysiological conditions associated with altered intracellular transport and dynamics.
The scientific importance of ACTR1B Gene Knockout Cell Lines lies in their applications across a multitude of research contexts, including neurobiology, cancer research, and developmental biology. By elucidating the mechanistic roles of ACTR1B, these cell lines can inspire novel therapeutic strategies aimed at restoring normal cellular functions in diseases where dynactin complex dysregulation is evident.
Compared to conventional knockdown methods, such as RNA interference, ACTR1B Gene Knockout Cell Lines provide a more stable and definitive model since the gene is permanently disrupted rather than functionally silenced. This permanence allows for more reproducible results and greater confidence in the observed biological outcomes.
For researchers and clinicians focused on the dynamic complexities of cellular functions, ACTR1B Gene Knockout Cell Lines offer a powerful platform that can drive innovative research initiatives and enhance understanding in crucial areas of study. Our company specializes in advanced genetic engineering techniques and is committed to providing high-quality, reliable products that empower scientific discovery and accelerate progress in diverse fields.
Please note that all services are for research use only. Not intended for any clinical use.
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