Gene: ACSL4
Official Full Name: acyl-CoA synthetase long chain family member 4provided by HGNC
Gene Summary: The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00872 | ACSL4 Knockout cell line(L-02) | Human | ACSL4 | 1:2~1:4 | Negative | Online Inquiry |
KO20031 | ACSL4 Knockout cell line (HeLa) | Human | ACSL4 | 1:3~1:6 | Negative | Online Inquiry |
KO20032 | ACSL4 Knockout cell line (HCT 116) | Human | ACSL4 | 1:2~1:4 | Negative | Online Inquiry |
KO20033 | ACSL4 Knockout cell line (HEK293) | Human | ACSL4 | 1:3~1:6 | Negative | Online Inquiry |
KO20034 | ACSL4 Knockout cell line (A549) | Human | ACSL4 | 1:3~1:4 | Negative | Online Inquiry |
ACSL4 Gene Knockout Cell Lines are sophisticated cellular models engineered to specifically disrupt the acyl-CoA synthetase long-chain family member 4 (ACSL4) gene. This gene encodes an enzyme critical for fatty acid metabolism, influencing various physiological and pathological processes, including cell proliferation, apoptosis, and inflammation. By utilizing CRISPR/Cas9 technology, these knockout cell lines provide an invaluable tool for researchers aiming to elucidate the specific functions of ACSL4 within cellular contexts.
The primary function of ACSL4 Gene Knockout Cell Lines lies in their ability to mimic the loss of ACSL4 expression, allowing for the investigation of its role in lipid metabolism and related signaling pathways. By understanding how the absence of ACSL4 affects cellular outcomes, researchers can uncover its implications in diseases such as cancer and metabolic disorders. These cell lines serve as experimental platforms for various applications, including drug discovery, metabolic profiling, and gene function studies in a controlled in vitro environment.
The scientific importance of these cell lines is underscored by their ability to facilitate the investigation of complex biological processes that involve lipid signaling and metabolism. Flexibility in experimental design makes them particularly suited for both basic research and translational studies aimed at developing targeted therapies. They stand out from alternative products due to their precise knockout design, validated functionality, and reproducibility, which enhance the reliability of experimental findings.
For researchers and clinicians, ACSL4 Gene Knockout Cell Lines represent a critical resource in exploring the underlying mechanisms of various diseases, potentially leading to novel insights and therapeutic strategies. Additionally, utilizing these specialized models can streamline the research process, saving time and resources while maximizing experimental outcomes.
As an industry leader in biological products, our company is committed to providing high-quality, scientifically validated cell lines that empower researchers to push the boundaries of discovery. Our expertise in genomic engineering ensures that our offerings meet the rigorous standards required for cutting-edge research applications.
Please note that all services are for research use only. Not intended for any clinical use.
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