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ACOT11 Knockout Cell Lines

Gene: ACOT11

Official Full Name: acyl-CoA thioesterase 11provided by HGNC

Gene Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28464 ACOT11 Knockout cell line (HeLa) Human ACOT11 1:3~1:6 Negative Online Inquiry
KO28465 ACOT11 Knockout cell line (HCT 116) Human ACOT11 1:2~1:4 Negative Online Inquiry
KO28466 ACOT11 Knockout cell line (HEK293) Human ACOT11 1:3~1:6 Negative Online Inquiry
KO28467 ACOT11 Knockout cell line (A549) Human ACOT11 1:3~1:4 Negative Online Inquiry

Background

ACOT11 Gene Knockout Cell Lines are engineered cell lines that have had the ACOT11 gene specifically disrupted through targeted gene editing techniques. This key genetic modification allows researchers to study the function and regulation of the ACOT11 gene, which is implicated in fatty acid metabolism and cellular lipid homeostasis. By using these knockout cell lines, scientists can investigate the biological consequences of ACOT11 deficiency, providing vital insights into metabolic disorders and potential therapeutic interventions.

The primary function of ACOT11 is to catalyze the hydrolysis of acyl-CoA to free fatty acids and CoA, a process that significantly influences cellular energy utilization and lipid signaling pathways. The careful manipulation of this gene creates an experimental model for evaluating how alterations in lipid metabolism can contribute to pathologies such as obesity, diabetes, and cardiovascular diseases. Researchers can employ these cell lines to elucidate the underlying molecular mechanisms, paving the way for novel therapeutic strategies.

In terms of scientific significance, ACOT11 Gene Knockout Cell Lines serve as a powerful tool in both basic and applied research. They allow for the detailed investigation of metabolic pathways, the assessment of drug responses, and the exploration of gene-environment interactions in disease states. Additionally, the use of these knockout lines can facilitate high-throughput screening for compounds that could modulate ACOT11 activity or compensate for its loss, presenting new avenues for drug discovery.

What sets our ACOT11 Gene Knockout Cell Lines apart is their precise gene editing, validated through rigorous genomic sequencing and functional assays, ensuring reliability and reproducibility in results. Unlike alternative models that may provide inconsistent data due to incomplete knockouts or variability in gene expression, our cell lines offer a stable, homogenous population that guarantees consistent experimental outcomes.

For researchers and clinicians striving to advance their understanding of lipid metabolism and its implications in health and disease, ACOT11 Gene Knockout Cell Lines are invaluable assets. They deliver a robust platform for experimentation, empowering scientists to uncover actionable insights that can lead to clinical breakthroughs. With a commitment to quality and innovation, our company stands as a leader in providing cutting-edge biological research tools designed to enhance scientific exploration and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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