Home / ACHE Knockout Cell Lines

ACHE Knockout Cell Lines

Gene: ACHE

Official Full Name: acetylcholinesterase (Yt blood group)provided by HGNC

Gene Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion[provided by RefSeq, Sep 2019]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39132 ACHE Knockout cell line (HCT 116) Human ACHE 1:2~1:4 Negative Online Inquiry
KO39133 ACHE Knockout cell line (A549) Human ACHE 1:3~1:4 Negative Online Inquiry

Background

ACHE Gene Knockout Cell Lines are specialized cellular models developed through advanced genetic engineering techniques to disrupt the expression of the acetylcholinesterase (ACHE) gene. This gene encodes an enzyme critical for the hydrolysis of the neurotransmitter acetylcholine, playing a vital role in neuromuscular transmission and neuronal signaling. By utilizing these knockout cell lines, researchers can effectively study the impact of ACHE absence on cellular processes and neurological diseases.

The primary function of ACHE Gene Knockout Cell Lines is to serve as a platform for investigating the physiological and pathological roles of acetylcholine signaling. These cell lines allow scientists to explore molecular pathways related to neurotransmission, synaptic plasticity, and potential drug responses in conditions such as Alzheimer's disease, myasthenia gravis, and other neurodegenerative disorders. The mechanisms underlying neuronal dysfunction can be modeled more accurately, facilitating a deeper understanding of disease mechanisms, and enabling the identification of novel therapeutic targets.

In the research field, the ACHE Gene Knockout Cell Lines present significant scientific importance, offering valuable insights into the role of acetylcholine in various physiological functions and disease states. Clinically, they provide an opportunity to develop new treatment avenues and evaluate the efficacy and mechanisms of pharmacological agents aimed at modulating cholinergic activity.

What sets our ACHE Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, achieved through precise CRISPR-Cas9 gene editing. This technology ensures that researchers can obtain consistent and reproducible results, which are crucial when translating laboratory findings into clinical applications. Additionally, our cell lines are extensively validated and characterized, guaranteeing authenticity and quality.

For researchers and clinicians alike, the ACHE Gene Knockout Cell Lines represent an invaluable tool in advancing the understanding of cholinergic signaling and its implications in human health. With a commitment to providing top-tier biological products and unwavering support, our company is dedicated to enhancing research outcomes and pioneering discoveries in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.