Gene: ACER2
Official Full Name: alkaline ceramidase 2provided by HGNC
Gene Summary: The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07635 | ACER2 Knockout cell line (HeLa) | Human | ACER2 | 1:3~1:6 | Negative | Online Inquiry |
KO07636 | ACER2 Knockout cell line (HCT 116) | Human | ACER2 | 1:2~1:4 | Negative | Online Inquiry |
KO07637 | ACER2 Knockout cell line (HEK293) | Human | ACER2 | 1:3~1:6 | Negative | Online Inquiry |
KO07638 | ACER2 Knockout cell line (A549) | Human | ACER2 | 1:3~1:4 | Negative | Online Inquiry |
ACER2 Gene Knockout Cell Lines are specifically engineered cellular models that have had the ACER2 gene inactivated, providing researchers with a powerful tool to study gene function, pathways, and related diseases. The ACER2 gene encodes a protein involved in lipid metabolism and cellular signaling, suggesting its potential roles in various metabolic disorders and cancer biology. By utilizing CRISPR/Cas9 technology or similar gene editing methods, these cell lines allow for precise alterations at the genetic level, enabling the investigation of ACER2's biological activities and its interactions with other cellular pathways.
The primary mechanism of functionality for ACER2 Gene Knockout Cell Lines lies in their capacity to emulate conditions of gene loss, mimicking disease states that are often challenging to study in vivo. Researchers can explore the ramifications of ACER2 depletion on cellular processes such as apoptosis, proliferation, and metabolic regulation. Such in vitro models are essential for elucidating the gene's role and assessing potential therapeutic pathways, thus paving the way for targeted interventions in diseases linked to ACER2 dysfunction.
The scientific importance of these cell lines extends beyond basic research; they hold significant value in drug discovery and development, allowing clinicians and biopharmaceutical companies to test the efficacy of new compounds in a controlled environment. Compared to traditional models, ACER2 Gene Knockout Cell Lines offer enhanced specificity and reliability for studying gene function and the mechanisms underpinning various pathologies.
Moreover, the advantages of using these particular cell lines include their robust validation processes and availability in multiple human and animal backgrounds, catering to a broad array of experimental designs. Researchers and clinicians can depend on these cell lines to yield reproducible and interpretable results, increasing the reliability of their findings.
With years of expertise in molecular biology and genetic engineering, our company consistently delivers high-quality biological products that bolster research and clinical development. The ACER2 Gene Knockout Cell Lines represent a key innovation in our product portfolio, empowering the scientific community to advance knowledge and therapeutic approaches in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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