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ABR Knockout Cell Lines

Gene: ABR

Official Full Name: ABR activator of RhoGEF and GTPaseprovided by HGNC

Gene Summary: This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO39151 ABR Knockout cell line (HeLa) Human ABR 1:3~1:6 Negative Online Inquiry
KO39152 ABR Knockout cell line (HCT 116) Human ABR 1:2~1:4 Negative Online Inquiry
KO39153 ABR Knockout cell line (HEK293) Human ABR 1:3~1:6 Negative Online Inquiry
KO39154 ABR Knockout cell line (A549) Human ABR 1:3~1:4 Negative Online Inquiry

Background

ABR Gene Knockout Cell Lines are meticulously developed cellular models designed to facilitate the study of the ABR gene’s function by creating a complete knockout of the gene’s expression in a variety of cell types. This innovative product serves as a powerful tool for researchers seeking to understand the regulatory mechanisms and biological pathways influenced by the ABR gene, which is known to play a crucial role in multiple cellular processes, including cell signaling and cytoskeletal dynamics.

The ABR Gene Knockout Cell Lines employ advanced CRISPR-Cas9 gene-editing technology to introduce targeted mutations in the ABR gene, resulting in a precise loss of function. This allows scientists to conduct functional assays that elucidate the gene's role in physiological and pathological contexts, particularly its involvement in cancer progression and neurodegenerative diseases. By utilizing these cell lines, researchers can explore the phenotypic consequences of ABR gene disruption in controlled conditions, expanding our understanding of its potential as a therapeutic target.

The scientific significance of the ABR Gene Knockout Cell Lines extends beyond basic research; they are invaluable in drug discovery and the development of novel therapeutic strategies. With the ability to model specific conditions reproducing human diseases, they can help identify new drug candidates and biomarkers, enhancing translational research efforts in clinical settings.

What sets the ABR Gene Knockout Cell Lines apart from alternative products on the market is not only their specificity and accuracy but also the extensive validation they undergo to ensure reproducibility and reliability in experimental outcomes. Researchers can trust these lines for consistent results, essential for rigorous scientific investigations.

In conclusion, the ABR Gene Knockout Cell Lines represent an exceptional resource for both academic and industrial laboratories focused on understanding gene function and its implications in various biological systems. Our company prides itself on providing high-quality biological products, backed by a team of experts in molecular biology and genetics, ensuring that our offerings meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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