Gene: ABI2
Official Full Name: abl interactor 2provided by HGNC
Gene Summary: Enables several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Part of SCAR complex. Is active in adherens junction. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32228 | ABI2 Knockout cell line (HeLa) | Human | ABI2 | 1:3~1:6 | Negative | Online Inquiry |
KO32229 | ABI2 Knockout cell line (HCT 116) | Human | ABI2 | 1:2~1:4 | Negative | Online Inquiry |
KO32230 | ABI2 Knockout cell line (HEK293) | Human | ABI2 | 1:3~1:6 | Negative | Online Inquiry |
KO32231 | ABI2 Knockout cell line (A549) | Human | ABI2 | 1:3~1:4 | Negative | Online Inquiry |
ABI2 Gene Knockout Cell Lines are specialized cultured cells that have been genetically engineered to disable the abi2 gene, a crucial regulator of various cellular processes including cytoskeletal dynamics and signal transduction pathways. Through a precise application of CRISPR-Cas9 technology, these knockout cell lines establish an invaluable platform for in-depth functional studies of the abi2 gene’s role in cellular behavior, particularly in relation to cancer progression and metastasis.
The primary function of ABI2 Gene Knockout Cell Lines lies in their ability to facilitate the exploration of signaling pathways that govern cellular motility and adhesion. By observing the differences in cellular responses between wild-type and knockout lines, researchers can delineate the impact of abi2 on key mechanisms such as cell migration, proliferation, and apoptosis. This functionality is critical in the context of cancer research, allowing scientists to interrogate the molecular underpinnings of tumorigenesis and to identify potential therapeutic targets.
The scientific significance of ABI2 Gene Knockout Cell Lines extends into both research and clinical settings, enabling investigators to contribute to the understanding of various pathologies, including cancer, cardiovascular diseases, and neurological disorders. The ability to derive insights into gene function and regulation through these models is essential for developing innovative treatment strategies.
One of the distinctive advantages of ABI2 Gene Knockout Cell Lines is their robust reliability and reproducibility compared to traditional gene silencing methods, such as RNA interference (RNAi). Whereas RNAi approaches can lead to incomplete or transient knockdown, CRISPR-based knockout ensures a stable and permanent deletion of the target gene, providing clearer insights into gene function.
Ultimately, ABI2 Gene Knockout Cell Lines represent a key resource for researchers and clinicians aiming to unlock the mysteries of gene functionality and its implications for health and disease. This product is invaluable for those who seek high-quality data that can translate to significant advancements in science and medicine. Our company prides itself on leveraging state-of-the-art genetic engineering techniques and a wealth of expertise in cell line development to offer products that enhance the precision of biological research and facilitate breakthroughs in therapeutic interventions.
Please note that all services are for research use only. Not intended for any clinical use.
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