Home / ABI1 Knockout Cell Lines

ABI1 Knockout Cell Lines

Gene: ABI1

Official Full Name: abl interactor 1provided by HGNC

Gene Summary: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32389 ABI1 Knockout cell line (HeLa) Human ABI1 1:3~1:6 Negative Online Inquiry
KO32390 ABI1 Knockout cell line (HCT 116) Human ABI1 1:2~1:4 Negative Online Inquiry
KO32391 ABI1 Knockout cell line (HEK293) Human ABI1 1:3~1:6 Negative Online Inquiry
KO32392 ABI1 Knockout cell line (A549) Human ABI1 1:3~1:4 Negative Online Inquiry

Background

ABI1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the ABI1 gene, which plays a pivotal role in various cellular processes, including actin dynamics and signal transduction pathways. These cell lines allow researchers to investigate the functional implications of ABI1 loss in biological systems, providing invaluable insights into mechanisms of cell motility, proliferation, and the potential dysregulation seen in cancer and other diseases.

The key function of ABI1 Gene Knockout Cell Lines lies in their ability to model the absence of ABI1 and its downstream effects on cellular behavior. By utilizing CRISPR/Cas9 technology or other genome editing strategies, the ABI1 gene is rendered non-functional, allowing for the examination of altered signaling cascades and cellular responses. Researchers can employ these cell lines to study morphogenetic processes, evaluate therapeutic targets, and assess drug responses in a controlled environment.

The scientific significance of these cell lines is underscored by their broad applicability across multiple fields, including cancer research, immunology, and developmental biology. In clinical settings, they serve as critical tools for drug discovery and validation, helping to elucidate the role of ABI1 in tumorigenesis and metastasis, while also offering a platform for the screening of novel therapeutic agents.

ABI1 Gene Knockout Cell Lines offer unique advantages over alternative models, including their precise gene editing, robust reproducibility, and ease of use in high-throughput assays. Unlike traditional knockout models that may be heterogeneous or cumbersome to produce, these engineered lines provide consistent results, delivering reliable data that can enhance the validity of research conclusions.

For researchers and clinicians alike, ABI1 Gene Knockout Cell Lines represent a crucial resource for advancing the understanding of cellular mechanisms and the development of targeted therapies. The ability to manipulate a specific gene in a controlled manner opens new avenues for experimentation and innovation in the life sciences.

Our company specializes in delivering high-quality, validated biological products, supported by years of expertise in genetic engineering and cell biology. We are committed to empowering researchers with the tools they need to drive scientific discovery and improve health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.