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ABHD4 Knockout Cell Lines

Gene: ABHD4

Official Full Name: abhydrolase domain containing 4, N-acyl phospholipase Bprovided by HGNC

Gene Summary: Predicted to enable lysophosphatidic acid acyltransferase activity and lysophospholipase activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; lipid homeostasis; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within N-acylethanolamine metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in lipid droplet and mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20082 ABHD4 Knockout cell line (HeLa) Human ABHD4 1:3~1:6 Negative Online Inquiry
KO20083 ABHD4 Knockout cell line (HCT 116) Human ABHD4 1:2~1:4 Negative Online Inquiry
KO20084 ABHD4 Knockout cell line (HEK293) Human ABHD4 1:3~1:6 Negative Online Inquiry
KO20085 ABHD4 Knockout cell line (A549) Human ABHD4 1:3~1:4 Negative Online Inquiry

Background

ABHD4 Gene Knockout Cell Lines are genetically engineered models specifically designed to facilitate the study of the Abhydrolase Domain-Containing 4 (ABHD4) gene and its associated protein functions. These cell lines exhibit a complete loss of ABHD4 expression due to targeted gene disruption, allowing for detailed investigations into the gene's role in various biological processes, particularly lipid metabolism and neurodegenerative disease pathways.

The key function of ABHD4 is its involvement in the hydrolysis of fatty acid amides, which plays a crucial role in modulating signaling pathways linked to inflammation and neural signaling. By using ABHD4 Gene Knockout Cell Lines, researchers can dissect the functional pathways influenced by ABHD4, enabling a better understanding of its contribution to physiological and pathological states. The knockout model serves as a crucial tool to explore the consequences of ABHD4 deficiency, including alterations in pharmacological responses and metabolic disorders.

The scientific importance of these cell lines is evident in their application in both basic research and potential therapeutic interventions. They are particularly valuable in drug discovery and development, allowing clinicians and researchers to screen for novel therapeutic agents that target lipid metabolism and neuroprotective strategies. Unlike traditional models, these knockout cell lines provide a more accurate representation of ABHD4's biological role, leading to insights that may be overlooked in wild-type models.

ABHD4 Gene Knockout Cell Lines present several advantages when compared to alternative models, including the specificity of gene disruption and the reproducibility of experimental results. This enables a more reliable interpretation of data, fostering advancements in understanding complex disease mechanisms associated with ABHD4.

To researchers and clinicians aiming to push the boundaries of biomedical knowledge, ABHD4 Gene Knockout Cell Lines serve as a powerful resource in the quest for innovative solutions to pressing health challenges. Our company is dedicated to providing high-quality, reliable biological products supported by extensive expertise in genetic engineering and molecular biology, ensuring that each product meets the rigorous standards required for groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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