Gene: ABHD2
Official Full Name: abhydrolase domain containing 2, acylglycerol lipaseprovided by HGNC
Gene Summary: This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a wide range of enzymes. The encoded protein is an acylglycerol lipase that catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol from the cell membrane. This leads to activation of the sperm calcium channel CatSper, which results in sperm activation. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31275 | ABHD2 Knockout cell line (HeLa) | Human | ABHD2 | 1:3~1:6 | Negative | Online Inquiry |
KO31276 | ABHD2 Knockout cell line (HCT 116) | Human | ABHD2 | 1:2~1:4 | Negative | Online Inquiry |
KO31277 | ABHD2 Knockout cell line (HEK293) | Human | ABHD2 | 1:3~1:6 | Negative | Online Inquiry |
KO31278 | ABHD2 Knockout cell line (A549) | Human | ABHD2 | 1:3~1:4 | Negative | Online Inquiry |
ABHD2 Gene Knockout Cell Lines represent a state-of-the-art tool designed for the functional analysis of the ABHD2 gene, which encodes a member of the α/β hydrolase superfamily involved in lipid metabolism and regulatory pathways in various biological systems. These engineered cell lines are created through advanced CRISPR-Cas9 gene editing technology, enabling researchers to investigate the impact of ABHD2 loss-of-function on cellular behavior, signaling cascades, and metabolic processes.
The core function of ABHD2 Gene Knockout Cell Lines lies in their ability to facilitate experimental studies that elucidate the physiological and pathological roles of the ABHD2 enzyme. By effectively silencing this gene, scientists are able to observe alterations in lipid signaling, inflammatory responses, and neuronal functions, making these cell lines indispensable in neurobiological, metabolic, and cancer research contexts. Such investigations are critical for understanding diseases associated with dysregulated lipid metabolism, including obesity, diabetes, and various types of cancer, where aberrant lipid signaling is implicated.
The scientific importance of these knockout cell lines extends beyond basic research; they serve as valuable models for drug discovery and toxicology assessments. Researchers can utilize these models to identify potential therapeutic compounds that modulate ABHD2 activity, providing insights that are crucial for developing targeted interventions in lipid-related diseases.
What differentiates our ABHD2 Gene Knockout Cell Lines from alternatives is the comprehensive validation process, ensuring consistent performance and reproducibility across experiments. With precise gene targeting and a high efficiency of knockout, these cell lines are an essential addition to labs seeking reliable models to explore lipid metabolic pathways.
For researchers and clinicians alike, ABHD2 Gene Knockout Cell Lines present an invaluable asset for translating basic scientific discoveries into clinical applications. Their role in enabling innovative research positions professionals to make significant strides in understanding and ultimately treating metabolic disorders and associated conditions.
Our company is committed to excellence in providing high-quality biological products and expertise in genetic engineering technologies, ensuring that our customers have access to the tools they need to advance their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.