Gene: AADAT
Official Full Name: aminoadipate aminotransferaseprovided by HGNC
Gene Summary: This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22918 | AADAT Knockout cell line (HeLa) | Human | AADAT | 1:3~1:6 | Negative | Online Inquiry |
KO22919 | AADAT Knockout cell line (HCT 116) | Human | AADAT | 1:2~1:4 | Negative | Online Inquiry |
KO22920 | AADAT Knockout cell line (HEK293) | Human | AADAT | 1:3~1:6 | Negative | Online Inquiry |
KO22921 | AADAT Knockout cell line (A549) | Human | AADAT | 1:3~1:4 | Negative | Online Inquiry |
AADAT Gene Knockout Cell Lines are specially developed cellular models that have undergone precise genetic modifications to disrupt the expression of the AADAT (aromatic L-amino acid decarboxylase) gene. These cell lines are invaluable tools in molecular biology for studying the genetic and biochemical pathways related to amino acid metabolism, neurotransmitter synthesis, and their implications in various neurodegenerative diseases and metabolic disorders.
The fundamental mechanism of action of the AADAT Gene Knockout Cell Lines involves the deletion of specific sequences within the AADAT gene, thereby rendering the encoded protein nonfunctional. This knockout allows researchers to investigate the phenotypic consequences of AADAT deficiency, including alterations in neurotransmitter levels, cell signaling pathways, and metabolic functions. This deep understanding is crucial in elucidating the role of AADAT in health and disease.
From a scientific perspective, these cell lines are pivotal in both research and clinical settings, enabling the exploration of therapeutic strategies targeting the pathways influenced by AADAT. They can be employed in drug discovery processes, screening for potential pharmacological agents, and understanding the molecular underpinnings of disorders such as Parkinson’s disease and schizophrenia.
Compared to traditional wild-type cell lines or other gene knockout models, AADAT Gene Knockout Cell Lines offer enhanced specificity and reliability, ensuring that findings are attributable to the specific genetic alteration. They are rigorously validated for consistent performance, yielding reproducible results that are critical for advancing scientific research.
The value of AADAT Gene Knockout Cell Lines extends beyond mere research applications, as they provide researchers and clinicians with high-quality tools that facilitate groundbreaking discoveries and innovative therapeutic developments. By providing insights into enzyme dysfunction and metabolic anomalies, these cell lines empower users to translate basic science into tangible clinical applications.
Our company, a leader in providing advanced biological products, brings years of expertise in cell line development and genetic engineering. We are committed to delivering innovative solutions that enhance experimental outcomes and drive scientific progress.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.