Gene: ZBTB33
Official Full Name: zinc finger and BTB domain containing 33provided by HGNC
Gene Summary: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00139 | Zbtb33 gRNA3-gRNA4 KO plasmid | Zbtb33 | $850 | |||
KO01124 | Zbtb33 Knockout cell line(4T1) | Mouse | Zbtb33 | 1:3~1:4 | Negative | Online Inquiry |
KO01142 | Zbtb33 Knockout cell line(RM-1) | Mouse | Zbtb33 | 1:3~1:4 | Negative | Online Inquiry |
ZBTB33 Gene Knockout Cell Lines represent a pivotal advancement in genetic research, designed for the targeted investigation of the ZBTB33 gene and its associated biological functions. ZBTB33, a member of the zinc finger and BTB domain-containing protein family, plays a crucial role in regulating gene expression and is implicated in various cellular processes, including cell differentiation, proliferation, and immune response mechanisms. The knockout of this gene in established cell lines enables researchers to study its loss-of-function effects, providing insights into its biological roles and aiding in the elucidation of disease mechanisms linked to its dysregulation.
These engineered cell lines utilize CRISPR/Cas9 technology to create precise deletions in the ZBTB33 gene, allowing researchers to investigate the downstream effects on cellular pathways and phenotypes. The ability to generate tailor-made knockout models facilitates the examination of ZBTB33's contributions to cancer biology, developmental disorders, and immune-related diseases, making these cell lines invaluable in both basic and translational research settings.
Compared to traditional genetic knockdown methods such as RNA interference, ZBTB33 Gene Knockout Cell Lines provide a permanent mutation that offers more robust and reproducible results, significantly enhancing the reliability of experimental outcomes. Their immediate utility in various assays, such as gene expression analysis, functional assays, and drug response studies, gives them a distinct advantage in exploration of novel therapeutic avenues.
Researchers and clinicians are encouraged to incorporate these knockout cell lines into their studies, as they not only advance our understanding of genetic regulation but also enable the identification of potential drug targets. By choosing ZBTB33 Gene Knockout Cell Lines, users benefit from a powerful tool in their research arsenal, backed by our company's extensive expertise in the development of high-quality biological products tailored for cutting-edge scientific inquiry. Our commitment to excellence ensures that each of our products meets rigorous standards, facilitating your research and accelerating the path to discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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